Evolution and Survival on Eutherian Sex Chromosomes Export

@article{citeulike:5193449, abstract = {Author Summary Using recently available marsupial and monotreme genomes, we investigated nascent sex chromosome evolution in mammals. We show that, in eutherian mammals, X and Y genes acquired distinct evolutionary rates and functional constraints immediately after recombination suppression; X-linked genes maintained lower, ancestral (autosomal), rates, whereas the evolutionary rates of Y-linked genes increased. Most X and, unexpectedly, Y genes evolved under stronger purifying selection than similarly aged autosomal paralogs. However, we also observed that the divergence of gametologs and paralogs shared similar features. In addition, many Y-linked copies evolved unique functions and expression patterns compared to their counterparts on the X chromosome. Therefore, our results suggest that to be retained on the Y chromosome, genes need to acquire separately valuable expression and/or functions to be safeguarded by purifying selection.}, author = {Wilson, Melissa A. and Makova, Kateryna D.}, citeulike-article-id = {5193449}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.1000568}, day = {17}, doi = {10.1371/journal.pgen.1000568}, journal = {PLoS Genet}, keywords = {chromosome, evolution, sex}, month = {July}, number = {7}, pages = {e1000568+}, posted-at = {2009-07-17 16:46:43}, priority = {2}, publisher = {Public Library of Science}, title = {Evolution and Survival on Eutherian Sex Chromosomes}, url = {http://dx.doi.org/10.1371/journal.pgen.1000568}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:5193449 L3 - citeulike-article-id:5193449 N2 - Author Summary Using recently available marsupial and monotreme genomes, we investigated nascent sex chromosome evolution in mammals. We show that, in eutherian mammals, X and Y genes acquired distinct evolutionary rates and functional constraints immediately after recombination suppression; X-linked genes maintained lower, ancestral (autosomal), rates, whereas the evolutionary rates of Y-linked genes increased. Most X and, unexpectedly, Y genes evolved under stronger purifying selection than similarly aged autosomal paralogs. However, we also observed that the divergence of gametologs and paralogs shared similar features. In addition, many Y-linked copies evolved unique functions and expression patterns compared to their counterparts on the X chromosome. Therefore, our results suggest that to be retained on the Y chromosome, genes need to acquire separately valuable expression and/or functions to be safeguarded by purifying selection. IS - 7 JF - PLoS Genet TI - Evolution and Survival on Eutherian Sex Chromosomes PB - Public Library of Science VL - 5 SP - e1000568 KW - chromosome KW - evolution KW - sex AU - Wilson, Melissa AU - Makova, Kateryna PY - 2009/07/17/ UR - http://dx.doi.org/10.1371/journal.pgen.1000568 ER -