Singapore Genome Variation Project: A haplotype map of three Southeast Asian populations. Export

@article{citeulike:5630094, abstract = {The Singapore Genome Variation Project (SGVP) provides a publicly available resource of 1.6 million single nucleotide polymorphisms (SNPs) genotyped in 268 individuals from the Chinese, Malay, and Indian population groups in Southeast Asia. This online database catalogs information and summaries on genotype and phased haplotype data, including allele frequencies, assessment of linkage disequilibrium (LD), and recombination rates in a format similar to the International HapMap Project. Here, we introduce this resource and describe the analysis of human genomic variation upon agglomerating data from the HapMap and the Human Genome Diversity Project, providing useful insights into the population structure of the three major population groups in Asia. In addition, this resource also surveyed across the genome for variation in regional patterns of LD between the HapMap and SGVP populations, and for signatures of positive natural selection using two well-established metrics: iHS and XP-EHH. The raw and processed genetic data, together with all population genetic summaries, are publicly available for download and browsing through a web browser modeled with the Generic Genome Browser.}, author = {Teo, Yik-Ying Y. and Sim, Xueling and Ong, Rick T. and Tan, Adrian K. and Chen, Jieming and Tantoso, Erwin and Small, Kerrin S. and Ku, Chee-Seng S. and Lee, Edmund J. and Seielstad, Mark and Chia, Kee-Seng S.}, citeulike-article-id = {5630094}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.095000.109}, citeulike-linkout-1 = {http://genome.cshlp.org/content/gr.095000.109v1/.abstract}, citeulike-linkout-2 = {http://genome.cshlp.org/content/gr.095000.109v1/.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19700652}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19700652}, day = {29}, doi = {10.1101/gr.095000.109}, issn = {1549-5477}, journal = {Genome research}, keywords = {demography, human, popgen, selection, snps}, month = {September}, number = {11}, pages = {2154--2162}, posted-at = {2009-11-02 18:11:32}, priority = {2}, title = {Singapore Genome Variation Project: A haplotype map of three Southeast Asian populations.}, url = {http://dx.doi.org/10.1101/gr.095000.109}, volume = {19}, year = {2009} }

TY - JOUR ID - citeulike:5630094 L3 - citeulike-article-id:5630094 N2 - The Singapore Genome Variation Project (SGVP) provides a publicly available resource of 1.6 million single nucleotide polymorphisms (SNPs) genotyped in 268 individuals from the Chinese, Malay, and Indian population groups in Southeast Asia. This online database catalogs information and summaries on genotype and phased haplotype data, including allele frequencies, assessment of linkage disequilibrium (LD), and recombination rates in a format similar to the International HapMap Project. Here, we introduce this resource and describe the analysis of human genomic variation upon agglomerating data from the HapMap and the Human Genome Diversity Project, providing useful insights into the population structure of the three major population groups in Asia. In addition, this resource also surveyed across the genome for variation in regional patterns of LD between the HapMap and SGVP populations, and for signatures of positive natural selection using two well-established metrics: iHS and XP-EHH. The raw and processed genetic data, together with all population genetic summaries, are publicly available for download and browsing through a web browser modeled with the Generic Genome Browser. IS - 11 JF - Genome research SN - 1549-5477 EP - 2162 TI - Singapore Genome Variation Project: A haplotype map of three Southeast Asian populations. VL - 19 SP - 2154 KW - demography KW - human KW - popgen KW - selection KW - snps AU - Teo, Yik-Ying AU - Sim, Xueling AU - Ong, Rick AU - Tan, Adrian AU - Chen, Jieming AU - Tantoso, Erwin AU - Small, Kerrin AU - Ku, Chee-Seng AU - Lee, Edmund AU - Seielstad, Mark AU - Chia, Kee-Seng PY - 2009/09/29/ UR - http://dx.doi.org/10.1101/gr.095000.109 ER -