Reconstructing Indian population history Export

@article{citeulike:5832760, abstract = {India has been underrepresented in genome-wide surveys of human variation. We analyse 25 diverse groups in India to provide strong evidence for two ancient populations, genetically divergent, that are ancestral to most Indians today. One, the 'Ancestral North Indians' (ANI), is genetically close to Middle Easterners, Central Asians, and Europeans, whereas the other, the 'Ancestral South Indians' (ASI), is as distinct from ANI and East Asians as they are from each other. By introducing methods that can estimate ancestry without accurate ancestral populations, we show that ANI ancestry ranges from 39–71\% in most Indian groups, and is higher in traditionally upper caste and Indo-European speakers. Groups with only ASI ancestry may no longer exist in mainland India. However, the indigenous Andaman Islanders are unique in being ASI-related groups without ANI ancestry. Allele frequency differences between groups in India are larger than in Europe, reflecting strong founder effects whose signatures have been maintained for thousands of years owing to endogamy. We therefore predict that there will be an excess of recessive diseases in India, which should be possible to screen and map genetically.}, author = {Reich, David and Thangaraj, Kumarasamy and Patterson, Nick and Price, Alkes L. and Singh, Lalji}, citeulike-article-id = {5832760}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature08365}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature08365}, day = {24}, doi = {10.1038/nature08365}, issn = {0028-0836}, journal = {Nature}, keywords = {admixture, demography, popgen}, month = {September}, number = {7263}, pages = {489--494}, posted-at = {2009-09-23 20:43:43}, priority = {2}, publisher = {Nature Publishing Group}, title = {Reconstructing Indian population history}, url = {http://dx.doi.org/10.1038/nature08365}, volume = {461}, year = {2009} }

TY - JOUR ID - citeulike:5832760 L3 - citeulike-article-id:5832760 N2 - India has been underrepresented in genome-wide surveys of human variation. We analyse 25 diverse groups in India to provide strong evidence for two ancient populations, genetically divergent, that are ancestral to most Indians today. One, the 'Ancestral North Indians' (ANI), is genetically close to Middle Easterners, Central Asians, and Europeans, whereas the other, the 'Ancestral South Indians' (ASI), is as distinct from ANI and East Asians as they are from each other. By introducing methods that can estimate ancestry without accurate ancestral populations, we show that ANI ancestry ranges from 39–71% in most Indian groups, and is higher in traditionally upper caste and Indo-European speakers. Groups with only ASI ancestry may no longer exist in mainland India. However, the indigenous Andaman Islanders are unique in being ASI-related groups without ANI ancestry. Allele frequency differences between groups in India are larger than in Europe, reflecting strong founder effects whose signatures have been maintained for thousands of years owing to endogamy. We therefore predict that there will be an excess of recessive diseases in India, which should be possible to screen and map genetically. IS - 7263 JF - Nature SN - 0028-0836 EP - 494 TI - Reconstructing Indian population history PB - Nature Publishing Group VL - 461 SP - 489 KW - admixture KW - demography KW - popgen AU - Reich, David AU - Thangaraj, Kumarasamy AU - Patterson, Nick AU - Price, Alkes AU - Singh, Lalji PY - 2009/09/24/ UR - http://dx.doi.org/10.1038/nature08365 ER -