The origins and impact of primate segmental duplications. Export

@article{citeulike:5884476, abstract = {Duplicated sequences are substrates for the emergence of new genes and are an important source of genetic instability associated with rare and common diseases. Analyses of primate genomes have shown an increase in the proportion of interspersed segmental duplications (SDs) within the genomes of humans and great apes. This contrasts with other mammalian genomes that seem to have their recently duplicated sequences organized in a tandem configuration. In this review, we focus on the mechanistic origin and impact of this difference with respect to evolution, genetic diversity and primate phenotype. Although many genomes will be sequenced in the future, resolution of this aspect of genomic architecture still requires high quality sequences and detailed analyses.}, author = {Marques-Bonet, Tomas and Girirajan, Santhosh and Eichler, Evan E.}, citeulike-article-id = {5884476}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2009.08.002}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0168952509001632}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19796838}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19796838}, day = {30}, doi = {10.1016/j.tig.2009.08.002}, issn = {0168-9525}, journal = {Trends in genetics : TIG}, keywords = {primates, review, sv}, month = {October}, number = {10}, pages = {443--454}, posted-at = {2009-10-21 18:54:28}, priority = {2}, title = {The origins and impact of primate segmental duplications.}, url = {http://dx.doi.org/10.1016/j.tig.2009.08.002}, volume = {25}, year = {2009} }

TY - JOUR ID - citeulike:5884476 L3 - citeulike-article-id:5884476 N2 - Duplicated sequences are substrates for the emergence of new genes and are an important source of genetic instability associated with rare and common diseases. Analyses of primate genomes have shown an increase in the proportion of interspersed segmental duplications (SDs) within the genomes of humans and great apes. This contrasts with other mammalian genomes that seem to have their recently duplicated sequences organized in a tandem configuration. In this review, we focus on the mechanistic origin and impact of this difference with respect to evolution, genetic diversity and primate phenotype. Although many genomes will be sequenced in the future, resolution of this aspect of genomic architecture still requires high quality sequences and detailed analyses. IS - 10 JF - Trends in genetics : TIG SN - 0168-9525 EP - 454 TI - The origins and impact of primate segmental duplications. VL - 25 SP - 443 KW - primates KW - review KW - sv AU - Marques-Bonet, Tomas AU - Girirajan, Santhosh AU - Eichler, Evan PY - 2009/10/30/ UR - http://dx.doi.org/10.1016/j.tig.2009.08.002 ER -