Intravenous immunoglobulins in autoimmune and inflammatory diseases: a mechanistic perspective. Export

@article{citeulike:3021119, abstract = {Initially used for the treatment of immunodeficiencies, intravenous immunoglobulins (IVIg) have increasingly been used as immunomodulatory agents in autoimmune and inflammatory disorders. The mode of action of IVIg is enigmatic, probably involving Fc-dependent and/or F(ab')2-dependent nonexclusive mechanisms of action. IVIg broadly interacts with the different components of the immune system: cytokines, complement, Fc receptors, and several cell surface immunocompetent molecules. IVIg has also an impact on effector functions of immune cells. These mechanisms of action of IVIg reflect the importance of natural antibodies in the maintenance of immune homeostasis. We discuss here the recent advances in the understanding of immunoregulatory effects of IVIg, and we pointed out the need for new strategies to overcome the predicted increasing worldwide shortage of IVIg.}, address = {INSERM UMRS 872, Universit\'{e} Ren\'{e} Descartes (Paris-5), Universit\'{e} Pierre et Marie Curie (UPMC Paris-6) 75006 Paris, France.}, author = {Sib\'{e}ril, S. and Elluru, S. and Graff-Dubois, S. and Negi, V. S. and Delignat, S. and Mouthon, L. and Lacroix-Desmazes, S. and Kazatchkine, M. D. and Bayary, J. and Kaveri, S. V.}, citeulike-article-id = {3021119}, citeulike-linkout-0 = {http://dx.doi.org/10.1196/annals.1423.052}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17911465}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17911465}, doi = {10.1196/annals.1423.052}, issn = {0077-8923}, journal = {Annals of the New York Academy of Sciences}, keywords = {ivig}, month = {September}, pages = {497--506}, posted-at = {2008-07-19 18:17:08}, priority = {2}, title = {Intravenous immunoglobulins in autoimmune and inflammatory diseases: a mechanistic perspective.}, url = {http://dx.doi.org/10.1196/annals.1423.052}, volume = {1110}, year = {2007} }

TY - JOUR ID - citeulike:3021119 L3 - citeulike-article-id:3021119 N2 - Initially used for the treatment of immunodeficiencies, intravenous immunoglobulins (IVIg) have increasingly been used as immunomodulatory agents in autoimmune and inflammatory disorders. The mode of action of IVIg is enigmatic, probably involving Fc-dependent and/or F(ab')2-dependent nonexclusive mechanisms of action. IVIg broadly interacts with the different components of the immune system: cytokines, complement, Fc receptors, and several cell surface immunocompetent molecules. IVIg has also an impact on effector functions of immune cells. These mechanisms of action of IVIg reflect the importance of natural antibodies in the maintenance of immune homeostasis. We discuss here the recent advances in the understanding of immunoregulatory effects of IVIg, and we pointed out the need for new strategies to overcome the predicted increasing worldwide shortage of IVIg. JF - Annals of the New York Academy of Sciences SN - 0077-8923 AD - INSERM UMRS 872, Université René Descartes (Paris-5), Université Pierre et Marie Curie (UPMC Paris-6) 75006 Paris, France. EP - 506 TI - Intravenous immunoglobulins in autoimmune and inflammatory diseases: a mechanistic perspective. VL - 1110 SP - 497 KW - ivig AU - Sibéril, S AU - Elluru, S AU - Graff-Dubois, S AU - Negi, VS AU - Delignat, S AU - Mouthon, L AU - Lacroix-Desmazes, S AU - Kazatchkine, MD AU - Bayary, J AU - Kaveri, SV PY - 2007/09// UR - http://dx.doi.org/10.1196/annals.1423.052 ER -