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Macrophage death and defective inflammation resolution in atherosclerosis

by: Ira Tabas
Nat Rev Immunol, Vol. 10, No. 1. (04 January 2010), pp. 36-46, doi:10.1038/nri2675  Key: citeulike:6485608

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Abstract

A key event in atherosclerosis is a maladaptive inflammatory response to subendothelial lipoproteins. A crucial aspect of this response is a failure to resolve inflammation, which normally involves the suppression of inflammatory cell influx, effective clearance of apoptotic cells and promotion of inflammatory cell egress.


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