Testing of a new pneumatic device to cause pain in humans Export

@article{Schubert92:Pain, abstract = {Background. Surgical pain typically combines superficial and deep pain. We wished to generate pain that resembled surgical pain, reliably and reproducibly, in volunteers. Methods. We constructed a computer-controlled pneumatic device to apply pressure to the anterior tibia. The reproducibility of the pain was tested by rating the pressure that caused pain rated 4-5 on a visual analogue scale (VAS) on days 0, 7, and 24 in 10 volunteers. The effect of remifentanil (0.025, 0.05, 0.075, and 0.1 microg kg-1 min-1) on pain tolerance in another set of volunteers (n=11) was used as an indirect measure of the reliability of pain production. Results. The pressure needed (0.7 (0.3) to 0.9 (0.4) atm (mean (SD)) to induce pain rated 4-5 (VAS) did not vary, showing long-term reproducibility of the method. When pressure was applied to cause increasing pain in volunteers (n=11) 0.05 microg kg-1 min-1 remifentanil increased pain tolerance by 50\%. An approximate doubling of the dose (0.1 microg kg-1 min-1) increased pain tolerance significantly more. The linear logarithmic dose-effect relationship shows that the device causes pain reliably, and this can be reduced with opioid treatment. Conclusion. This pneumatic device can apply pain reliably and reproducibly. Br J Anaesth 2004; 92: 532-5 10.1093/bja/aeh097}, author = {Schubert, H. M. and Lorenz, I. H. and Zschiegner, F. and Kremser, C. and Hohlrieder, M. and Biebl, M. and Kolbitsch, C. and Moser, P. L.}, citeulike-article-id = {1304408}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/bja/aeh097}, citeulike-linkout-1 = {http://bja.oxfordjournals.org/cgi/content/abstract/92/4/532}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/14766716}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=14766716}, day = {1}, doi = {10.1093/bja/aeh097}, journal = {Br. J. Anaesth.}, keywords = {humor, medicine}, month = {April}, number = {4}, pages = {532--535}, posted-at = {2007-05-18 01:04:16}, priority = {2}, title = {Testing of a new pneumatic device to cause pain in humans}, url = {http://dx.doi.org/10.1093/bja/aeh097}, volume = {92}, year = {2004} }

TY - JOUR ID - Schubert92:Pain L3 - citeulike-article-id:1304408 N2 - Background. Surgical pain typically combines superficial and deep pain. We wished to generate pain that resembled surgical pain, reliably and reproducibly, in volunteers. Methods. We constructed a computer-controlled pneumatic device to apply pressure to the anterior tibia. The reproducibility of the pain was tested by rating the pressure that caused pain rated 4-5 on a visual analogue scale (VAS) on days 0, 7, and 24 in 10 volunteers. The effect of remifentanil (0.025, 0.05, 0.075, and 0.1 microg kg-1 min-1) on pain tolerance in another set of volunteers (n=11) was used as an indirect measure of the reliability of pain production. Results. The pressure needed (0.7 (0.3) to 0.9 (0.4) atm (mean (SD)) to induce pain rated 4-5 (VAS) did not vary, showing long-term reproducibility of the method. When pressure was applied to cause increasing pain in volunteers (n=11) 0.05 microg kg-1 min-1 remifentanil increased pain tolerance by 50%. An approximate doubling of the dose (0.1 microg kg-1 min-1) increased pain tolerance significantly more. The linear logarithmic dose-effect relationship shows that the device causes pain reliably, and this can be reduced with opioid treatment. Conclusion. This pneumatic device can apply pain reliably and reproducibly. Br J Anaesth 2004; 92: 532-5 10.1093/bja/aeh097 IS - 4 JF - Br. J. Anaesth. EP - 535 TI - Testing of a new pneumatic device to cause pain in humans VL - 92 SP - 532 KW - humor KW - medicine AU - Schubert, HM AU - Lorenz, IH AU - Zschiegner, F AU - Kremser, C AU - Hohlrieder, M AU - Biebl, M AU - Kolbitsch, C AU - Moser, PL PY - 2004/04/01/ UR - http://dx.doi.org/10.1093/bja/aeh097 ER -