Organization of 'nanocrystal molecules' using DNA

@article{Alivisatos1996, abstract = {PATTERNING matter on the nanometre scale is an important objective of current materials chemistry and physics. It is driven by both the need to further miniaturize electronic components and the fact that at the nanometre scale, materials properties are strongly size-dependent and thus can be tuned sensitively1. In nanoscale crystals, quantum size effects and the large number of surface atoms influence the, chemical, electronic, magnetic and optical behaviour2—4. 'Top-down' (for example, lithographic) methods for nanoscale manipulation reach only to the upper end of the nanometre regime5; but whereas 'bottom-up' wet chemical techniques allow for the preparation of mono-disperse, defect-free crystallites just 1–10 nm in size6–10, ways to control the structure of nanocrystal assemblies are scarce. Here we describe a strategy for the synthesis of'nanocrystal molecules', in which discrete numbers of gold nanocrystals are organized into spatially defined structures based on Watson-Crick base-pairing interactions. We attach single-stranded DNA oligonucleotides of defined length and sequence to individual nanocrystals, and these assemble into dimers and trimers on addition of a complementary single-stranded DNA template. We anticipate that this approach should allow the construction of more complex two-and three-dimensional assemblies.}, author = {Alivisatos, Paul A. and Johnsson, Kai P. and Peng, Xiaogang and Wilson, Troy E. and Loweth, Colin J. and Bruchez, Marcel P. and Schultz, Peter G. }, citeulike-article-id = {1702493}, doi = {http://dx.doi.org/10.1038/382609a0}, journal = {Nature}, keywords = {lit-sem-1, metallization, metallization-au, nanogold, origami, tem-dna, tem-nanogold}, number = {6592}, pages = {609--611}, posted-at = {2007-09-27 19:41:53}, priority = {3}, title = {Organization of 'nanocrystal molecules' using DNA}, url = {http://dx.doi.org/10.1038/382609a0}, volume = {382}, year = {1996} }

TY - JOUR ID - Alivisatos1996 L3 - citeulike-article-id:1702493 TI - Organization of 'nanocrystal molecules' using DNA JF - Nature VL - 382 IS - 6592 SP - 609 EP - 611 N2 - PATTERNING matter on the nanometre scale is an important objective of current materials chemistry and physics. It is driven by both the need to further miniaturize electronic components and the fact that at the nanometre scale, materials properties are strongly size-dependent and thus can be tuned sensitively1. In nanoscale crystals, quantum size effects and the large number of surface atoms influence the, chemical, electronic, magnetic and optical behaviour2—4. 'Top-down' (for example, lithographic) methods for nanoscale manipulation reach only to the upper end of the nanometre regime5; but whereas 'bottom-up' wet chemical techniques allow for the preparation of mono-disperse, defect-free crystallites just 1–10 nm in size6–10, ways to control the structure of nanocrystal assemblies are scarce. Here we describe a strategy for the synthesis of'nanocrystal molecules', in which discrete numbers of gold nanocrystals are organized into spatially defined structures based on Watson-Crick base-pairing interactions. We attach single-stranded DNA oligonucleotides of defined length and sequence to individual nanocrystals, and these assemble into dimers and trimers on addition of a complementary single-stranded DNA template. We anticipate that this approach should allow the construction of more complex two-and three-dimensional assemblies. KW - lit-sem-1 KW - metallization KW - metallization-au KW - nanogold KW - origami KW - tem-dna KW - tem-nanogold AU - Alivisatos, Paul AU - Johnsson, Kai AU - Peng, Xiaogang AU - Wilson, Troy AU - Loweth, Colin AU - Bruchez, Marcel AU - Schultz, Peter PY - 1996//15/ UR - http://dx.doi.org/10.1038/382609a0 ER -