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The developments of semisynthetic DNA-protein conjugates

by: Christof M Niemeyer
Trends in Biotechnology, Vol. 20, No. 9. (1 September 2002), pp. 395-401.

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Semisynthetic DNA-protein conjugates, generated by either covalent or non-covalent coupling chemistry, are versatile molecular tools applicable in bioanalytical and synthetic chemical procedures. This article reviews the synthesis and characterization of artificial nucleic acid-protein conjugates, in addition to applications arising in the life sciences and nanobiotechnology, such as the self-assembly of high-affinity reagents for immunological detection assays and biosensors, the fabrication of laterally microstructured biochips, and the biomimetic `bottom-up' synthesis of nanostructured supramolecular devices.


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