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Gold nanoparticle decoration of DNA on silicon.

by: G Braun, K Inagaki, RA Estabrook, DK Wood, E Levy, AN Cleland, GF Strouse, NO Reich
Langmuir : the ACS journal of surfaces and colloids, Vol. 21, No. 23. (8 November 2005), pp. 10699-10701.


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Electrostatic assembly of cationic nanoparticles onto the negatively charged backbone of double-stranded DNA has been shown to produce one-dimensional chains with potential use as nanoelectronic components. In this paper, micron long DNA templates stretched on aminosilane- and hexamethyldisilazane-modified silicon surfaces are used to assemble 3.5 nm gold nanoparticles passivated with cationic thiocholine. Atomic force microscopy is used to analyze the density and defects along the approximately 5 nm high structures, with comparison between positively charged and neutral surfaces. Low background adsorption of nanoparticles is facilitated by both these surface chemistries, while the neutral surface yields a more densely packed assembly.


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