Synthesis from DNA of a molecule with the connectivity of a cube.

@article{citeulike:504168, abstract = {A principal goal of biotechnology is the assembly of novel biomaterials for analytical, industrial and therapeutic purposes. The advent of stable immobile nucleic acid branched junctions makes DNA a good candidate for building frameworks to which proteins or other functional molecules can be attached and thereby juxtaposed. The addition of single-stranded 'sticky' ends to branched DNA molecules converts them into macromolecular valence clusters that can be ligated together. The edges of these frameworks are double-helical DNA, and the vertices correspond to the branch points of junctions. Here, we report the construction from DNA of a covalently closed cube-like molecular complex containing twelve equal-length double-helical edges arranged about eight vertices. Each of the six 'faces' of the object is a single-stranded cyclic molecule, doubly catenated to four neighbouring strands, and each vertex is connected by an edge to three others. Each edge contains a unique restriction site for analytical purposes. This is the first construction of a closed polyhedral object from DNA.}, address = {Department of Chemistry, New York University, New York 10003.}, author = {Chen, J. H. and Seeman, N. C. }, citeulike-article-id = {504168}, doi = {10.1038/350631a0}, issn = {0028-0836}, journal = {Nature}, keywords = {background, origami}, month = {April}, number = {6319}, pages = {631--633}, posted-at = {2008-04-30 13:50:32}, priority = {2}, title = {Synthesis from DNA of a molecule with the connectivity of a cube.}, url = {http://dx.doi.org/10.1038/350631a0}, volume = {350}, year = {1991} }

TY - JOUR ID - citeulike:504168 L3 - citeulike-article-id:504168 TI - Synthesis from DNA of a molecule with the connectivity of a cube. JF - Nature VL - 350 IS - 6319 SP - 631 EP - 633 AD - Department of Chemistry, New York University, New York 10003. SN - 0028-0836 N2 - A principal goal of biotechnology is the assembly of novel biomaterials for analytical, industrial and therapeutic purposes. The advent of stable immobile nucleic acid branched junctions makes DNA a good candidate for building frameworks to which proteins or other functional molecules can be attached and thereby juxtaposed. The addition of single-stranded 'sticky' ends to branched DNA molecules converts them into macromolecular valence clusters that can be ligated together. The edges of these frameworks are double-helical DNA, and the vertices correspond to the branch points of junctions. Here, we report the construction from DNA of a covalently closed cube-like molecular complex containing twelve equal-length double-helical edges arranged about eight vertices. Each of the six 'faces' of the object is a single-stranded cyclic molecule, doubly catenated to four neighbouring strands, and each vertex is connected by an edge to three others. Each edge contains a unique restriction site for analytical purposes. This is the first construction of a closed polyhedral object from DNA. KW - background KW - origami AU - Chen, JH AU - Seeman, NC PY - 1991/04/18/ UR - http://dx.doi.org/10.1038/350631a0 ER -