Population Genetic Inference From Resequencing Data Export

@article{citeulike:3477626, abstract = {This article is concerned with statistical modeling of shotgun resequencing data and the use of such data for population genetic inference. We model data produced by sequencing-by-synthesis technologies such as the Solexa, 454, and polymerase colony (polony) systems, whose use is becoming increasingly widespread. We show how such data can be used to estimate evolutionary parameters (mutation and recombination rates), despite the fact that the data do not necessarily provide complete or aligned sequence information. We also present two refinements of our methods: one that is more robust to sequencing errors and another that can be used when no reference genome is available. 10.1534/genetics.107.080630}, author = {Jiang, Rong and Tavare, Simon and Marjoram, Paul}, booktitle = {Genetics}, citeulike-article-id = {3477626}, citeulike-linkout-0 = {http://dx.doi.org/10.1534/genetics.107.080630}, citeulike-linkout-1 = {http://www.genetics.org/cgi/content/abstract/181/1/187?etoc}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18984575}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18984575}, day = {1}, doi = {10.1534/genetics.107.080630}, issn = {0016-6731}, journal = {Genetics}, keywords = {454, method, next\_gen\_sequencing, parameter\_estimation, solexa}, month = {January}, number = {1}, pages = {187--197}, posted-at = {2009-01-15 17:08:28}, priority = {2}, title = {Population Genetic Inference From Resequencing Data}, url = {http://dx.doi.org/10.1534/genetics.107.080630}, volume = {181}, year = {2009} }

TY - JOUR ID - citeulike:3477626 L3 - citeulike-article-id:3477626 N2 - This article is concerned with statistical modeling of shotgun resequencing data and the use of such data for population genetic inference. We model data produced by sequencing-by-synthesis technologies such as the Solexa, 454, and polymerase colony (polony) systems, whose use is becoming increasingly widespread. We show how such data can be used to estimate evolutionary parameters (mutation and recombination rates), despite the fact that the data do not necessarily provide complete or aligned sequence information. We also present two refinements of our methods: one that is more robust to sequencing errors and another that can be used when no reference genome is available. 10.1534/genetics.107.080630 IS - 1 JF - Genetics SN - 0016-6731 EP - 197 TI - Population Genetic Inference From Resequencing Data VL - 181 T2 - Genetics SP - 187 KW - 454 KW - method KW - next_gen_sequencing KW - parameter_estimation KW - solexa AU - Jiang, Rong AU - Tavare, Simon AU - Marjoram, Paul PY - 2009/01/01/ UR - http://dx.doi.org/10.1534/genetics.107.080630 ER -