Proteins, drug targets and the mechanisms they control: the simple truth about complex networks Export

@article{citeulike:1807984, abstract = {Realizing the promise of molecularly targeted inhibitors for cancer therapy will require a new level of knowledge about how a drug target is wired into the control circuitry of a complex cellular network. Here we review general homeostatic principles of cellular networks that enable the cell to be resilient in the face of molecular perturbations, while at the same time being sensitive to subtle input signals. Insights into such mechanisms may facilitate the development of combination therapies that take advantage of the cellular control circuitry, with the aim of achieving higher efficacy at a lower drug dosage and with a reduced probability of drug-resistance development.}, address = {The authors are all at the Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Boulevard, Manassas, Virginia 20109, USA.}, author = {Araujo, Robyn P. and Liotta, Lance A. and Petricoin, Emanuel F.}, citeulike-article-id = {1807984}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrd2381}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrd2381}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17932492}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17932492}, day = {12}, doi = {10.1038/nrd2381}, issn = {1474-1784}, journal = {Nat Rev Drug Discov}, keywords = {drug\_discovery, networks}, month = {November}, number = {11}, pages = {871--880}, posted-at = {2007-11-02 18:45:35}, priority = {2}, publisher = {Nature Publishing Group}, title = {Proteins, drug targets and the mechanisms they control: the simple truth about complex networks}, url = {http://dx.doi.org/10.1038/nrd2381}, volume = {6}, year = {2007} }

TY - JOUR ID - citeulike:1807984 L3 - citeulike-article-id:1807984 N2 - Realizing the promise of molecularly targeted inhibitors for cancer therapy will require a new level of knowledge about how a drug target is wired into the control circuitry of a complex cellular network. Here we review general homeostatic principles of cellular networks that enable the cell to be resilient in the face of molecular perturbations, while at the same time being sensitive to subtle input signals. Insights into such mechanisms may facilitate the development of combination therapies that take advantage of the cellular control circuitry, with the aim of achieving higher efficacy at a lower drug dosage and with a reduced probability of drug-resistance development. IS - 11 JF - Nat Rev Drug Discov SN - 1474-1784 AD - The authors are all at the Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Boulevard, Manassas, Virginia 20109, USA. EP - 880 TI - Proteins, drug targets and the mechanisms they control: the simple truth about complex networks PB - Nature Publishing Group VL - 6 SP - 871 KW - drug_discovery KW - networks AU - Araujo, Robyn AU - Liotta, Lance AU - Petricoin, Emanuel PY - 2007/11/12/ UR - http://dx.doi.org/10.1038/nrd2381 ER -