Gene expression profiling in an in vitro model of angiogenesis. Export

@article{Kahn2000, abstract = {In the present study we have used a novel, comprehensive mRNA profiling technique (GeneCalling) for determining differential gene expression profiles of human endothelial cells undergoing differentiation into tubelike structures. One hundred fifteen cDNA fragments were identified and shown to represent 90 distinct genes. Although some of the genes identified have previously been implicated in angiogenesis, potential roles for many new genes, including OX-40, white protein homolog, KIAA0188, a homolog of angiopoietin-2, ADAMTS-4 (aggrecanase-1), and stanniocalcin were revealed. Support for the biological significance was confirmed by the abrogation of the changes in the expression of angiogenesis inhibitors and in situ hybridization studies. This study has significantly extends the molecular fingerprint of the changes in gene expression that occur during endothelial differentiation and provides new insights into the potential role of a number of new molecules in angiogenesis.}, author = {Kahn, J. and Mehraban, F. and Ingle, G. and Xin, X. and Bryant, J. E. and Vehar, G. and Schoenfeld, J. and Grimaldi, C. J. and Peale, F. and Draksharapu, A. and Lewin, D. A. and Gerritsen, M. E.}, citeulike-article-id = {3488495}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10854212}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10854212}, issn = {0002-9440}, journal = {The American journal of pathology}, keywords = {angiogenesis, gene\_expression}, month = {June}, number = {6}, pages = {1887--1900}, posted-at = {2008-11-07 16:06:01}, priority = {2}, title = {Gene expression profiling in an in vitro model of angiogenesis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10854212}, volume = {156}, year = {2000} }

TY - JOUR ID - Kahn2000 L3 - citeulike-article-id:3488495 N2 - In the present study we have used a novel, comprehensive mRNA profiling technique (GeneCalling) for determining differential gene expression profiles of human endothelial cells undergoing differentiation into tubelike structures. One hundred fifteen cDNA fragments were identified and shown to represent 90 distinct genes. Although some of the genes identified have previously been implicated in angiogenesis, potential roles for many new genes, including OX-40, white protein homolog, KIAA0188, a homolog of angiopoietin-2, ADAMTS-4 (aggrecanase-1), and stanniocalcin were revealed. Support for the biological significance was confirmed by the abrogation of the changes in the expression of angiogenesis inhibitors and in situ hybridization studies. This study has significantly extends the molecular fingerprint of the changes in gene expression that occur during endothelial differentiation and provides new insights into the potential role of a number of new molecules in angiogenesis. IS - 6 JF - The American journal of pathology SN - 0002-9440 EP - 1900 TI - Gene expression profiling in an in vitro model of angiogenesis. VL - 156 SP - 1887 KW - angiogenesis KW - gene_expression AU - Kahn, J AU - Mehraban, F AU - Ingle, G AU - Xin, X AU - Bryant, JE AU - Vehar, G AU - Schoenfeld, J AU - Grimaldi, CJ AU - Peale, F AU - Draksharapu, A AU - Lewin, DA AU - Gerritsen, ME PY - 2000/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/10854212 ER -