Identification of biomarkers for tumor endothelial cell proliferation through gene expression profiling. Export

@article{Hardwick2005, abstract = {Extensive efforts are under way to identify antiangiogenic therapies for the treatment of human cancers. Many proposed therapeutics target vascular endothelial growth factor (VEGF) or the kinase insert domain receptor (KDR/VEGF receptor-2/FLK-1), the mitogenic VEGF receptor tyrosine kinase expressed by endothelial cells. Inhibition of KDR catalytic activity blocks tumor neoangiogenesis, reduces vascular permeability, and, in animal models, inhibits tumor growth and metastasis. Using a gene expression profiling strategy in rat tumor models, we identified a set of six genes that are selectively overexpressed in tumor endothelial cells relative to tumor cells and whose pattern of expression correlates with the rate of tumor endothelial cell proliferation. In addition to being potential targets for antiangiogenesis tumor therapy, the expression patterns of these genes or their protein products may aid the development of pharmacodynamic assays for small molecule inhibitors of the KDR kinase in human tumors.}, author = {Hardwick, James S. and Yang, Yi and Zhang, Chunsheng and Shi, Bin and McFall, Rosemary and Koury, Elizabeth J. and Hill, Susan L. and Dai, Hongyue and Wasserman, Robert and Phillips, Robert L. and Weinstein, Edward J. and Kohl, Nancy E. and Severino, Michael E. and Lamb, John R. and Sepp-Lorenzino, Laura}, citeulike-article-id = {5710151}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/1535-7163.MCT-04-0209}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15767550}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15767550}, doi = {10.1158/1535-7163.MCT-04-0209}, issn = {1535-7163}, journal = {Molecular cancer therapeutics}, keywords = {angiogenesis}, month = {March}, number = {3}, pages = {413--425}, posted-at = {2009-09-02 21:26:00}, priority = {2}, title = {Identification of biomarkers for tumor endothelial cell proliferation through gene expression profiling.}, url = {http://dx.doi.org/10.1158/1535-7163.MCT-04-0209}, volume = {4}, year = {2005} }

TY - JOUR ID - Hardwick2005 L3 - citeulike-article-id:5710151 N2 - Extensive efforts are under way to identify antiangiogenic therapies for the treatment of human cancers. Many proposed therapeutics target vascular endothelial growth factor (VEGF) or the kinase insert domain receptor (KDR/VEGF receptor-2/FLK-1), the mitogenic VEGF receptor tyrosine kinase expressed by endothelial cells. Inhibition of KDR catalytic activity blocks tumor neoangiogenesis, reduces vascular permeability, and, in animal models, inhibits tumor growth and metastasis. Using a gene expression profiling strategy in rat tumor models, we identified a set of six genes that are selectively overexpressed in tumor endothelial cells relative to tumor cells and whose pattern of expression correlates with the rate of tumor endothelial cell proliferation. In addition to being potential targets for antiangiogenesis tumor therapy, the expression patterns of these genes or their protein products may aid the development of pharmacodynamic assays for small molecule inhibitors of the KDR kinase in human tumors. IS - 3 JF - Molecular cancer therapeutics SN - 1535-7163 EP - 425 TI - Identification of biomarkers for tumor endothelial cell proliferation through gene expression profiling. VL - 4 SP - 413 KW - angiogenesis AU - Hardwick, James AU - Yang, Yi AU - Zhang, Chunsheng AU - Shi, Bin AU - McFall, Rosemary AU - Koury, Elizabeth AU - Hill, Susan AU - Dai, Hongyue AU - Wasserman, Robert AU - Phillips, Robert AU - Weinstein, Edward AU - Kohl, Nancy AU - Severino, Michael AU - Lamb, John AU - Sepp-Lorenzino, Laura PY - 2005/03// UR - http://dx.doi.org/10.1158/1535-7163.MCT-04-0209 ER -