Impact of family hypertension history on exercise-induced cardiac remodeling. Export

@article{citeulike:5052630, abstract = {Left ventricular (LV) hypertrophy is a well-established, but highly variable, finding among exercise-trained persons. The causes for the variability in LV remodeling in response to exercise training remain incompletely understood. The present study sought to determine whether a family history of hypertension is a determinant of the cardiac response to exercise training. The cardiac parameters in 60 collegiate rowers (30 men/30 women; age 19.8 +/- 1.1 years) with (family history positive [FH+], n = 22) and without (family history negative [FH-], n = 38) a FH of hypertension were studied with echocardiography before and after 90 days of rowing training. The LV mass increased significantly in both groups. However, the LV mass increased significantly more in FH- persons (Delta 17 +/- 5 g/m(2)) than in FH+ persons (Delta 9 +/- 6 g/m(2), p <0.001) with distinctly differently patterns of LV hypertrophy between the 2 groups. FH- athletes experienced eccentric LV hypertrophy (relative wall thickness index 0.39 +/- 0.4) characterized by LV dilation. In contrast, FH+ athletes developed concentric LV hypertrophy (relative wall thickness index 0.44 +/- 0.3; p <0.001) characterized by LV wall thickening. Furthermore, the eccentric LV remodeling in FH- athletes was associated with a more robust enhancement of LV diastolic function than the concentric LV remodeling that occurred in FH+ athletes. In conclusion, these findings suggest that patterns of exercise-induced LV remodeling are strongly associated with FH history status.}, author = {Baggish, A. L. and Weiner, R. B. and Yared, K. and Wang, F. and Kupperman, E. and Hutter, A. M. and Picard, M. H. and Wood, M. J.}, citeulike-article-id = {5052630}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.amjcard.2009.02.052}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0002914909006791}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19576328}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19576328}, day = {1}, doi = {10.1016/j.amjcard.2009.02.052}, issn = {1879-1913}, journal = {The American journal of cardiology}, keywords = {family, history, hypertension}, month = {July}, number = {1}, pages = {101--106}, posted-at = {2009-07-12 14:17:51}, priority = {2}, title = {Impact of family hypertension history on exercise-induced cardiac remodeling.}, url = {http://dx.doi.org/10.1016/j.amjcard.2009.02.052}, volume = {104}, year = {2009} }

TY - JOUR ID - citeulike:5052630 L3 - citeulike-article-id:5052630 N2 - Left ventricular (LV) hypertrophy is a well-established, but highly variable, finding among exercise-trained persons. The causes for the variability in LV remodeling in response to exercise training remain incompletely understood. The present study sought to determine whether a family history of hypertension is a determinant of the cardiac response to exercise training. The cardiac parameters in 60 collegiate rowers (30 men/30 women; age 19.8 +/- 1.1 years) with (family history positive [FH+], n = 22) and without (family history negative [FH-], n = 38) a FH of hypertension were studied with echocardiography before and after 90 days of rowing training. The LV mass increased significantly in both groups. However, the LV mass increased significantly more in FH- persons (Delta 17 +/- 5 g/m(2)) than in FH+ persons (Delta 9 +/- 6 g/m(2), p <0.001) with distinctly differently patterns of LV hypertrophy between the 2 groups. FH- athletes experienced eccentric LV hypertrophy (relative wall thickness index 0.39 +/- 0.4) characterized by LV dilation. In contrast, FH+ athletes developed concentric LV hypertrophy (relative wall thickness index 0.44 +/- 0.3; p <0.001) characterized by LV wall thickening. Furthermore, the eccentric LV remodeling in FH- athletes was associated with a more robust enhancement of LV diastolic function than the concentric LV remodeling that occurred in FH+ athletes. In conclusion, these findings suggest that patterns of exercise-induced LV remodeling are strongly associated with FH history status. IS - 1 JF - The American journal of cardiology SN - 1879-1913 EP - 106 TI - Impact of family hypertension history on exercise-induced cardiac remodeling. VL - 104 SP - 101 KW - family KW - history KW - hypertension AU - Baggish, AL AU - Weiner, RB AU - Yared, K AU - Wang, F AU - Kupperman, E AU - Hutter, AM AU - Picard, MH AU - Wood, MJ PY - 2009/07/01/ UR - http://dx.doi.org/10.1016/j.amjcard.2009.02.052 ER -