The COP1–SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity Export

@article{citeulike:4222167, abstract = {10.1101/gad.1122903 COP1 is a constitutive repressor of photomorphogenesis that interacts with photomorphogenesis-promoting factors such as HY5 to promote their proteasome-mediated degradation. SPA1 is a repressor of phytochrome A-mediated responses to far-red light. Here we report that COP1 acts as part of a large protein complex and interacts with SPA1 in a light-dependent manner. We further demonstrate the E3 ubiquitin ligase activity of COP1 on HY5 in vitro and the alteration of that activity by SPA1. Thus, the COP1-SPA1 interaction defines a critical step in coordinating COP1-mediated ubiquitination and subsequent degradation of HY5 with PHYA signaling.}, author = {Saijo, Yusuke and Sullivan, James A. and Wang, Haiyang and Yang, Jianping and Shen, Yunping and Rubio, Vicente and Ma, Ligeng and Hoecker, Ute and Deng, Xing W.}, citeulike-article-id = {4222167}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gad.1122903}, citeulike-linkout-1 = {http://genesdev.cshlp.org/content/17/21/2642.full.abstract}, citeulike-linkout-2 = {http://genesdev.cshlp.org/content/17/21/2642.full.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/14597662}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=14597662}, day = {1}, doi = {10.1101/gad.1122903}, journal = {Genes \& Development}, keywords = {cop1, hy5, spa1}, month = {November}, number = {21}, pages = {2642--2647}, posted-at = {2009-03-26 13:44:38}, priority = {2}, title = {The COP1–SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity}, url = {http://dx.doi.org/10.1101/gad.1122903}, volume = {17}, year = {2003} }

TY - JOUR ID - citeulike:4222167 L3 - citeulike-article-id:4222167 N2 - 10.1101/gad.1122903 COP1 is a constitutive repressor of photomorphogenesis that interacts with photomorphogenesis-promoting factors such as HY5 to promote their proteasome-mediated degradation. SPA1 is a repressor of phytochrome A-mediated responses to far-red light. Here we report that COP1 acts as part of a large protein complex and interacts with SPA1 in a light-dependent manner. We further demonstrate the E3 ubiquitin ligase activity of COP1 on HY5 in vitro and the alteration of that activity by SPA1. Thus, the COP1-SPA1 interaction defines a critical step in coordinating COP1-mediated ubiquitination and subsequent degradation of HY5 with PHYA signaling. IS - 21 JF - Genes & Development EP - 2647 TI - The COP1–SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity VL - 17 SP - 2642 KW - cop1 KW - hy5 KW - spa1 AU - Saijo, Yusuke AU - Sullivan, James AU - Wang, Haiyang AU - Yang, Jianping AU - Shen, Yunping AU - Rubio, Vicente AU - Ma, Ligeng AU - Hoecker, Ute AU - Deng, Xing PY - 2003/11/01/ UR - http://dx.doi.org/10.1101/gad.1122903 ER -