Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease Export

@article{citeulike:5378082, abstract = {Abstract\ \ Now that the laboratory mouse genome is sequenced and the annotation of its gene content is improving, the next major challenge is the annotation of the phenotypic associations of mouse genes. This requires the development of systematic phenotyping pipelines that use standardized phenotyping procedures which allow comparison across laboratories. It also requires the development of a sophisticated informatics infrastructure for the description and interchange of phenotype data. Here we focus on the current state of the art in the description of data produced by systematic phenotyping approaches using ontologies, in particular, the EQ (Entity-Quality) approach, and what developments are required to facilitate the linking of phenotypic descriptions of mutant mice to human diseases.}, author = {Hancock, John and Mallon, Ann-Marie and Beck, Tim and Gkoutos, Georgios and Mungall, Chris and Schofield, Paul}, citeulike-article-id = {5378082}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00335-009-9208-3}, citeulike-linkout-1 = {http://www.springerlink.com/content/4685435t42085n43}, day = {1}, doi = {10.1007/s00335-009-9208-3}, journal = {Mammalian Genome}, keywords = {semantic-web}, month = {August}, number = {8}, pages = {457--461}, posted-at = {2009-10-30 10:52:15}, priority = {2}, title = {Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease}, url = {http://dx.doi.org/10.1007/s00335-009-9208-3}, volume = {20}, year = {2009} }

TY - JOUR ID - citeulike:5378082 L3 - citeulike-article-id:5378082 N2 - Abstract  Now that the laboratory mouse genome is sequenced and the annotation of its gene content is improving, the next major challenge is the annotation of the phenotypic associations of mouse genes. This requires the development of systematic phenotyping pipelines that use standardized phenotyping procedures which allow comparison across laboratories. It also requires the development of a sophisticated informatics infrastructure for the description and interchange of phenotype data. Here we focus on the current state of the art in the description of data produced by systematic phenotyping approaches using ontologies, in particular, the EQ (Entity-Quality) approach, and what developments are required to facilitate the linking of phenotypic descriptions of mutant mice to human diseases. IS - 8 JF - Mammalian Genome EP - 461 TI - Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease VL - 20 SP - 457 KW - semantic-web AU - Hancock, John AU - Mallon, Ann-Marie AU - Beck, Tim AU - Gkoutos, Georgios AU - Mungall, Chris AU - Schofield, Paul PY - 2009/08/01/ UR - http://dx.doi.org/10.1007/s00335-009-9208-3 ER -