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Statistical basis for the determination of optical pathlength in tissue. Export

Phys Med Biol, Vol. 40, No. 9. (Sep 1995), pp. 1539-1558.

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8532764 animals bibtex-import carlo confidence drbbibtex-import humans infrared intervals light mathematics method models monte of processes reproducibility results spectrophotometry statistical stochastic

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In this paper we show how to derive the mean and variance of the transilluminated signal obtained in models of light propagation in tissue, based both on a stochastic Monte Carlo method and on a deterministic diffusion approximation. The theoretical treatment of the Monte Carlo model applies only to integrated intensity measurements, whereas the diffusion approximation gives an estimator for the time-dependent case as well. We present results that show the accurate prediction of Monte Carlo statistics, and propose that the diffusion approximation is therefore a suitable mechanism for incorporating noise into modelling procedures.


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