Indocyanine green hyperfluorescence associated with serous retinal pigment epithelial detachment in age-related macular degeneration. Export

@article{Baumal1997, abstract = {PURPOSE: Indocyanine green (ICG) angiography may improve visualization of choroidal neovascularization (CNV) associated with serous retinal pigment epithelial detachment (RPED) in age-related macular degeneration (AMD). The features of ICG hyperfluorescence associated with serous RPED and therapeutic effect of ICG-directed laser photocoagulation in eyes with serous RPED is evaluated. DESIGN: Retrospective review of all simultaneous fluorescein/ICG angiograms (n = 918) performed over an 18-month period to identify 44 eyes in 39 patients with serous RPED secondary to AMD on fluorescein angiography. PARTICIPANTS: Thirty-nine patients with AMD, aged 53 to 89 years, participated. INTERVENTION: Eyes were nonrandomly treated with ICG-directed laser photocoagulation or observation. MAIN OUTCOME MEASURES: Characteristics of ICG hyperfluorescence associated with a serous RPED are reviewed. Final visual acuity and anatomic appearance of the serous RPED are given. RESULTS: Twenty-three (52\%) of the 44 eyes had an isolated serous RPED without obvious CNV, and 21 (48\%) of the 44 eyes had a serous RPED associated with occult CNV on fluorescein angiography. Indocyanine green angiography demonstrated underlying CNV in 19 eyes (83\%) with an isolated serous RPED and in all 21 eyes (100\%) with serous RPED and occult CNV. The pattern of ICG hyperfluorescence revealed focal CNV in 15 eyes and plaque CNV in 4 eyes with an isolated serous RPED. In eyes with serous RPED and occult CNV, focal CNV and plaque CNV were noted with ICG in 8 and 13 eyes, respectively. No follow-up was available for two eyes. Twenty eyes were treated with ICG-directed laser photocoagulation. In these eyes, the visual acuity remained stable in 6 eyes (30\%) and decreased in 14 eyes (70\%). Twenty-two eyes were observed, and the visual acuity remained stable in 8 (36\%), improved in 2 (9\%), and decreased in 12 eyes (55\%). CONCLUSIONS: Although ICG angiography may enhance visualization of CNV associated with serous RPED in AMD, ICG-directed laser treatment did not appear to improve visual acuity when compared with observed eyes in this series.}, author = {Baumal, C. R. and Reichel, E. and Duker, J. S. and Wong, J. and Puliafito, C. A.}, citeulike-article-id = {2642937}, journal = {Ophthalmology}, keywords = {80, acuity, aged, agents, and, angiography, bibtex-import, coagulation, coloring, degeneration, detachment, drbbibtex-import, epithelium, eye, female, fluorescein, follow-up, fundus, green, humans, indocyanine, laser, macular, male, middle, oculi, of, outcome, over, pigment, retinal, retrospective, studies, treatment, visual}, month = {May}, number = {5}, pages = {761--769}, posted-at = {2008-04-08 22:43:39}, priority = {2}, title = {Indocyanine green hyperfluorescence associated with serous retinal pigment epithelial detachment in age-related macular degeneration.}, volume = {104}, year = {1997} }

TY - JOUR ID - Baumal1997 L3 - citeulike-article-id:2642937 N2 - PURPOSE: Indocyanine green (ICG) angiography may improve visualization of choroidal neovascularization (CNV) associated with serous retinal pigment epithelial detachment (RPED) in age-related macular degeneration (AMD). The features of ICG hyperfluorescence associated with serous RPED and therapeutic effect of ICG-directed laser photocoagulation in eyes with serous RPED is evaluated. DESIGN: Retrospective review of all simultaneous fluorescein/ICG angiograms (n = 918) performed over an 18-month period to identify 44 eyes in 39 patients with serous RPED secondary to AMD on fluorescein angiography. PARTICIPANTS: Thirty-nine patients with AMD, aged 53 to 89 years, participated. INTERVENTION: Eyes were nonrandomly treated with ICG-directed laser photocoagulation or observation. MAIN OUTCOME MEASURES: Characteristics of ICG hyperfluorescence associated with a serous RPED are reviewed. Final visual acuity and anatomic appearance of the serous RPED are given. RESULTS: Twenty-three (52%) of the 44 eyes had an isolated serous RPED without obvious CNV, and 21 (48%) of the 44 eyes had a serous RPED associated with occult CNV on fluorescein angiography. Indocyanine green angiography demonstrated underlying CNV in 19 eyes (83%) with an isolated serous RPED and in all 21 eyes (100%) with serous RPED and occult CNV. The pattern of ICG hyperfluorescence revealed focal CNV in 15 eyes and plaque CNV in 4 eyes with an isolated serous RPED. In eyes with serous RPED and occult CNV, focal CNV and plaque CNV were noted with ICG in 8 and 13 eyes, respectively. No follow-up was available for two eyes. Twenty eyes were treated with ICG-directed laser photocoagulation. In these eyes, the visual acuity remained stable in 6 eyes (30%) and decreased in 14 eyes (70%). Twenty-two eyes were observed, and the visual acuity remained stable in 8 (36%), improved in 2 (9%), and decreased in 12 eyes (55%). CONCLUSIONS: Although ICG angiography may enhance visualization of CNV associated with serous RPED in AMD, ICG-directed laser treatment did not appear to improve visual acuity when compared with observed eyes in this series. IS - 5 JF - Ophthalmology EP - 769 TI - Indocyanine green hyperfluorescence associated with serous retinal pigment epithelial detachment in age-related macular degeneration. VL - 104 SP - 761 KW - 80 KW - acuity KW - aged KW - agents KW - and KW - angiography KW - bibtex-import KW - coagulation KW - coloring KW - degeneration KW - detachment KW - drbbibtex-import KW - epithelium KW - eye KW - female KW - fluorescein KW - follow-up KW - fundus KW - green KW - humans KW - indocyanine KW - laser KW - macular KW - male KW - middle KW - oculi KW - of KW - outcome KW - over KW - pigment KW - retinal KW - retrospective KW - studies KW - treatment KW - visual AU - Baumal, CR AU - Reichel, E AU - Duker, JS AU - Wong, J AU - Puliafito, CA PY - 1997/May// ER -