Initial clinical experience with contrast-enhanced digital breast tomosynthesis. Export

@article{Chen2007, abstract = {RATIONALE AND OBJECTIVES: Contrast-enhanced digital mammography and digital breast tomosynthesis are two imaging techniques that attempt to increase malignant breast lesion conspicuity. The combination of these into a single technique, contrast-enhanced digital breast tomosynthesis (CE-DBT), could potentially integrate the strengths of both. The objectives of this study were to assess the clinical feasibility of CE-DBT as an adjunct to digital mammography, and to correlate lesion enhancement characteristics and morphology obtained with CE-DBT to digital mammography, ultrasound, and magnetic resonance (MR). MATERIALS AND METHODS: CE-DBT (GE Senographe 2000D; Milwaukee, WI) was performed as a pilot study in an ongoing National Cancer Institute-funded grant (P01-CA85484) studying multimodality breast imaging. Thirteen patients with ACR BI-RADS category 4 or 5 breast lesions underwent imaging with digital mammography, ultrasound, MR, and CE-DBT. CE-DBT was performed at 49 kVp with a rhodium target and a 0.27-mm copper (Alfa Aesar, Ward Hill, MA) filter. Preinjection and postinjection DBT image sets were acquired in the medial lateral oblique projection with slight compression. Each image set consists of nine images acquired over a 50-degree arc and was obtained with a mean glandular x-ray dose comparable to two conventional mammographic views. Between the precontrast and postcontrast DBT image sets, a single bolus of iodinated contrast agent (1 ml/kg at 2 ml/s, Omnipaque-300; Amersham Health Inc., Princeton, NJ) was administered. Images were reconstructed using filtered-backprojection in 1-mm increments and transmitted to a clinical PACS workstation. RESULTS: Initial experience suggests that CE-DBT provides morphologic and vascular characteristics of breast lesions qualitatively concordant with that of digital mammography and MR. CONCLUSION: As an adjunct to digital mammography, CE-DBT may be a potential alternative tool for breast lesion morphologic and vascular characterization.}, author = {Chen, Sara C. and Carton, Ann K. and Albert, Michael and Conant, Emily F. and Schnall, Mitchell D. and Maidment, Andrew D. A.}, citeulike-article-id = {2642963}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.acra.2006.10.022}, doi = {10.1016/j.acra.2006.10.022}, journal = {Acad Radiol}, keywords = {acids, adult, aged, bibtex-import, breast, computer-assisted, contrast, drbbibtex-import, enhancement, humans, image, interpretation, mammography, media, middle, neoplasms, neovascularization, pathologic, pilot, projects, radiographic, tomography, triiodobenzoic}, month = {Feb}, number = {2}, pages = {229--238}, posted-at = {2008-04-08 22:43:42}, priority = {2}, title = {Initial clinical experience with contrast-enhanced digital breast tomosynthesis.}, url = {http://dx.doi.org/10.1016/j.acra.2006.10.022}, volume = {14}, year = {2007} }

TY - JOUR ID - Chen2007 L3 - citeulike-article-id:2642963 N2 - RATIONALE AND OBJECTIVES: Contrast-enhanced digital mammography and digital breast tomosynthesis are two imaging techniques that attempt to increase malignant breast lesion conspicuity. The combination of these into a single technique, contrast-enhanced digital breast tomosynthesis (CE-DBT), could potentially integrate the strengths of both. The objectives of this study were to assess the clinical feasibility of CE-DBT as an adjunct to digital mammography, and to correlate lesion enhancement characteristics and morphology obtained with CE-DBT to digital mammography, ultrasound, and magnetic resonance (MR). MATERIALS AND METHODS: CE-DBT (GE Senographe 2000D; Milwaukee, WI) was performed as a pilot study in an ongoing National Cancer Institute-funded grant (P01-CA85484) studying multimodality breast imaging. Thirteen patients with ACR BI-RADS category 4 or 5 breast lesions underwent imaging with digital mammography, ultrasound, MR, and CE-DBT. CE-DBT was performed at 49 kVp with a rhodium target and a 0.27-mm copper (Alfa Aesar, Ward Hill, MA) filter. Preinjection and postinjection DBT image sets were acquired in the medial lateral oblique projection with slight compression. Each image set consists of nine images acquired over a 50-degree arc and was obtained with a mean glandular x-ray dose comparable to two conventional mammographic views. Between the precontrast and postcontrast DBT image sets, a single bolus of iodinated contrast agent (1 ml/kg at 2 ml/s, Omnipaque-300; Amersham Health Inc., Princeton, NJ) was administered. Images were reconstructed using filtered-backprojection in 1-mm increments and transmitted to a clinical PACS workstation. RESULTS: Initial experience suggests that CE-DBT provides morphologic and vascular characteristics of breast lesions qualitatively concordant with that of digital mammography and MR. CONCLUSION: As an adjunct to digital mammography, CE-DBT may be a potential alternative tool for breast lesion morphologic and vascular characterization. IS - 2 JF - Acad Radiol EP - 238 TI - Initial clinical experience with contrast-enhanced digital breast tomosynthesis. VL - 14 SP - 229 KW - acids KW - adult KW - aged KW - bibtex-import KW - breast KW - computer-assisted KW - contrast KW - drbbibtex-import KW - enhancement KW - humans KW - image KW - interpretation KW - mammography KW - media KW - middle KW - neoplasms KW - neovascularization KW - pathologic KW - pilot KW - projects KW - radiographic KW - tomography KW - triiodobenzoic AU - Chen, Sara AU - Carton, Ann AU - Albert, Michael AU - Conant, Emily AU - Schnall, Mitchell AU - Maidment, Andrew PY - 2007/Feb// UR - http://dx.doi.org/10.1016/j.acra.2006.10.022 ER -