Autoregulation of Cerebral Blood Flow in Fetuses with Congenital Heart Disease: The Brain Sparing Effect Export

@article{citeulike:3025038, abstract = {Fetuses with congenital heart disease (CHD) have circulatory abnormalities that may compromise cerebral oxygen delivery. We believe that some CHD fetuses with decreased cerebral oxygen supply have autoregulation of blood flow that enhances cerebral perfusion (brain sparing). We hypothesize that cerebral autoregulation occurs in CHD fetuses, and the degree of autoregulation is dependent on the specific CHD and correlates with intrauterine head circumferences. CHD fetuses were compared to normal fetuses. Data included cardiac diagnosis, cerebral and umbilical artery Doppler, head circumference, weight, and gestational age. The cerebral-to-placental resistance ratio (CPR) was assessed as a measure of cerebral autoregulation. CPR = cerebral/umbilical resistance index (RI) and RI = systolic\&\#8211;diastolic/systolic velocity (normal CPR>1). CPR>1 was found in 95\% of normal vs 44\% of CHD fetuses. The incidence of CPR 2 kg with CHD and a CPR<1 had smaller head circumferences than normal. Brain sparing occurs in CHD fetuses. Fetuses with single ventricular physiology are most affected. Inadequate cerebral flow in CHD fetuses, despite autoregulation, may alter brain growth.}, author = {Donofrio, M. T. and Bremer, Y. A. and Schieken, R. M. and Gennings, C. and Morton, L. D. and Eidem, B. W. and Cetta, F. and Falkensammer, C. B. and Huhta, J. C. and Kleinman, C. S.}, citeulike-article-id = {3025038}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00246-002-0404-0}, day = {1}, doi = {10.1007/s00246-002-0404-0}, journal = {Pediatric Cardiology}, keywords = {autoregulation, bloodflow, cbf, cerebralbloodflow, chd, congenitalheartdefect, neonatal, neonate, neurology}, number = {5}, pages = {436--443}, posted-at = {2008-07-21 18:04:53}, priority = {2}, title = {Autoregulation of Cerebral Blood Flow in Fetuses with Congenital Heart Disease: The Brain Sparing Effect}, url = {http://dx.doi.org/10.1007/s00246-002-0404-0}, volume = {24}, year = {2003} }

TY - JOUR ID - citeulike:3025038 L3 - citeulike-article-id:3025038 N2 - Fetuses with congenital heart disease (CHD) have circulatory abnormalities that may compromise cerebral oxygen delivery. We believe that some CHD fetuses with decreased cerebral oxygen supply have autoregulation of blood flow that enhances cerebral perfusion (brain sparing). We hypothesize that cerebral autoregulation occurs in CHD fetuses, and the degree of autoregulation is dependent on the specific CHD and correlates with intrauterine head circumferences. CHD fetuses were compared to normal fetuses. Data included cardiac diagnosis, cerebral and umbilical artery Doppler, head circumference, weight, and gestational age. The cerebral-to-placental resistance ratio (CPR) was assessed as a measure of cerebral autoregulation. CPR = cerebral/umbilical resistance index (RI) and RI = systolic&#8211;diastolic/systolic velocity (normal CPR>1). CPR>1 was found in 95% of normal vs 44% of CHD fetuses. The incidence of CPR 2 kg with CHD and a CPR<1 had smaller head circumferences than normal. Brain sparing occurs in CHD fetuses. Fetuses with single ventricular physiology are most affected. Inadequate cerebral flow in CHD fetuses, despite autoregulation, may alter brain growth. IS - 5 JF - Pediatric Cardiology EP - 443 TI - Autoregulation of Cerebral Blood Flow in Fetuses with Congenital Heart Disease: The Brain Sparing Effect VL - 24 SP - 436 KW - autoregulation KW - bloodflow KW - cbf KW - cerebralbloodflow KW - chd KW - congenitalheartdefect KW - neonatal KW - neonate KW - neurology AU - Donofrio, MT AU - Bremer, YA AU - Schieken, RM AU - Gennings, C AU - Morton, LD AU - Eidem, BW AU - Cetta, F AU - Falkensammer, CB AU - Huhta, JC AU - Kleinman, CS PY - 2003//01/ UR - http://dx.doi.org/10.1007/s00246-002-0404-0 ER -