Cerebral oxygen saturation before congenital heart surgery Export

@article{citeulike:3250830, abstract = {Background. In congenital heart disease (CHD), neurologic abnormalities suggestive of hypoxia-ischemia are often apparent before cardiac surgery. To evaluate preoperative cerebral oxygenation, this study determined cerebral O2 saturation (ScO2) in CHD and healthy children. Methods. Ninety-one CHD and 19 healthy children aged less than 7 years were studied before surgical or radiologic procedures. Arterial saturation (SaO2) and ScO2 were measured by pulse-oximetry and near infrared cerebral oximetry. Cerebral O2 extraction (CEO2) was calculated (Sa-ScO2). SaO2, ScO2, and CEO2 were compared among diagnoses. Multivariable regression was performed between ScO2 and clinical variables. Results. In healthy subjects, ScO2 (68\% ± 10\%) and CEO2 (30\% ± 11\%) were similar to patients with ventricular septal defect, aortic coarctation, and single ventricle after Fontan operation. ScO2 was significantly decreased in patients with patent ductus arteriosus (53\% ± 8\%), tetralogy of Fallot (57\% ± 12\%), hypoplastic left heart syndrome (46\% ± 8\%), pulmonary atresia (38\% ± 6\%), and single ventricle after aortopulmonary shunt (50\% ± 7\%), or bidirectional Glenn operation (43\% ± 6\%). CEO2 was significantly different only in patent ductus arteriosus (46\% ± 8\%) and hypoplastic left heart syndrome (38\% ± 12\%). In multivariable regression, only SaO2 was related to ScO2 (R = 0.63, p < 0.001). Conclusions. Cerebral oxygenation in CHD varies with anatomy and arterial saturation, and in some patients, it is very low compared with healthy subjects.}, author = {Kurth, Dean C. and Steven, James L. and Montenegro, Lisa M. and Watzman, Marc H. and Gaynor, William J. and Spray, Thomas L. and Nicolson, Susan C.}, citeulike-article-id = {3250830}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0003-4975(01)02632-7}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T11-43B3J7S-1C/2/1814fb0ac5789cb8c8fa19e1e0fd605b}, doi = {10.1016/S0003-4975(01)02632-7}, journal = {The Annals of Thoracic Surgery}, keywords = {cerebral, chd, congenital, congenitalheart, congenitalheartdefect, kurth, nirs, oxygenation}, month = {July}, number = {1}, pages = {187--192}, posted-at = {2008-09-12 18:34:14}, priority = {2}, title = {Cerebral oxygen saturation before congenital heart surgery}, url = {http://dx.doi.org/10.1016/S0003-4975(01)02632-7}, volume = {72}, year = {2001} }

TY - JOUR ID - citeulike:3250830 L3 - citeulike-article-id:3250830 N2 - Background. In congenital heart disease (CHD), neurologic abnormalities suggestive of hypoxia-ischemia are often apparent before cardiac surgery. To evaluate preoperative cerebral oxygenation, this study determined cerebral O2 saturation (ScO2) in CHD and healthy children. Methods. Ninety-one CHD and 19 healthy children aged less than 7 years were studied before surgical or radiologic procedures. Arterial saturation (SaO2) and ScO2 were measured by pulse-oximetry and near infrared cerebral oximetry. Cerebral O2 extraction (CEO2) was calculated (Sa-ScO2). SaO2, ScO2, and CEO2 were compared among diagnoses. Multivariable regression was performed between ScO2 and clinical variables. Results. In healthy subjects, ScO2 (68% ± 10%) and CEO2 (30% ± 11%) were similar to patients with ventricular septal defect, aortic coarctation, and single ventricle after Fontan operation. ScO2 was significantly decreased in patients with patent ductus arteriosus (53% ± 8%), tetralogy of Fallot (57% ± 12%), hypoplastic left heart syndrome (46% ± 8%), pulmonary atresia (38% ± 6%), and single ventricle after aortopulmonary shunt (50% ± 7%), or bidirectional Glenn operation (43% ± 6%). CEO2 was significantly different only in patent ductus arteriosus (46% ± 8%) and hypoplastic left heart syndrome (38% ± 12%). In multivariable regression, only SaO2 was related to ScO2 (R = 0.63, p < 0.001). Conclusions. Cerebral oxygenation in CHD varies with anatomy and arterial saturation, and in some patients, it is very low compared with healthy subjects. IS - 1 JF - The Annals of Thoracic Surgery EP - 192 TI - Cerebral oxygen saturation before congenital heart surgery VL - 72 SP - 187 KW - cerebral KW - chd KW - congenital KW - congenitalheart KW - congenitalheartdefect KW - kurth KW - nirs KW - oxygenation AU - Kurth, Dean AU - Steven, James AU - Montenegro, Lisa AU - Watzman, Marc AU - Gaynor, William AU - Spray, Thomas AU - Nicolson, Susan PY - 2001/07// UR - http://dx.doi.org/10.1016/S0003-4975(01)02632-7 ER -