Near-infrared monitoring of the cerebral circulation Export

@article{citeulike:3250853, abstract = {Near-infrared spectroscopy is a noninvasive bedside technique for monitoring hemoglobin saturation (HbO2\%) in brain vasculature. The method linearly relates the optical signal detected from the surface of the head to HbO2\%. To do so, the method relies on constant transcranial optical pathlength and light scattering as well as minimal interference by tissues overlying the brain. This study examined these premises. Optical signals from a dual-wavelength, near-infrared spectrometer were correlated with sagittal sinus HbO2\% in 7 anesthetized piglets subjected to 7 different physiological conditions: normoxia, moderate and severe hypoxia, hyperoxia, hypocapnia, hypercapnic hyperoxia, and hypotension. These conditions were induced by varying the inspired O2 concentration (7–100\%),k ventilatory rate (5–35 breaths/min), and blood pressure (phlebotomy 20 ml/kg) to force HbO2\% over a wide range (5–93\%). To evaluate interference by tissues overlying the brain, correlations were repeated after the scalp and skull were rendered ischemic. Transcranial optical pathlength was measured by phase-modulated spectroscopy. Linear relationships between optical signals and sagittal sinus HbO2\% were found with correlation coefficients ranging from -0.89 to -0.99 (p2\% in the clinical setting, further study is recommended before the method can be used to manage patients.}, author = {Kurth, Dean C. and Steven, J. M. and Benaron, D. and Chance, B.}, citeulike-article-id = {3250853}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/BF01617023}, day = {11}, doi = {10.1007/BF01617023}, journal = {Journal of Clinical Monitoring and Computing}, keywords = {cerebral, chance, kurth, nearinfrared, nirs, piglet, review}, month = {October}, number = {3}, pages = {163--170}, posted-at = {2008-09-12 18:59:11}, priority = {2}, title = {Near-infrared monitoring of the cerebral circulation}, url = {http://dx.doi.org/10.1007/BF01617023}, volume = {9}, year = {1992} }

TY - JOUR ID - citeulike:3250853 L3 - citeulike-article-id:3250853 N2 - Near-infrared spectroscopy is a noninvasive bedside technique for monitoring hemoglobin saturation (HbO2%) in brain vasculature. The method linearly relates the optical signal detected from the surface of the head to HbO2%. To do so, the method relies on constant transcranial optical pathlength and light scattering as well as minimal interference by tissues overlying the brain. This study examined these premises. Optical signals from a dual-wavelength, near-infrared spectrometer were correlated with sagittal sinus HbO2% in 7 anesthetized piglets subjected to 7 different physiological conditions: normoxia, moderate and severe hypoxia, hyperoxia, hypocapnia, hypercapnic hyperoxia, and hypotension. These conditions were induced by varying the inspired O2 concentration (7–100%),k ventilatory rate (5–35 breaths/min), and blood pressure (phlebotomy 20 ml/kg) to force HbO2% over a wide range (5–93%). To evaluate interference by tissues overlying the brain, correlations were repeated after the scalp and skull were rendered ischemic. Transcranial optical pathlength was measured by phase-modulated spectroscopy. Linear relationships between optical signals and sagittal sinus HbO2% were found with correlation coefficients ranging from -0.89 to -0.99 (p2% in the clinical setting, further study is recommended before the method can be used to manage patients. IS - 3 JF - Journal of Clinical Monitoring and Computing EP - 170 TI - Near-infrared monitoring of the cerebral circulation VL - 9 SP - 163 KW - cerebral KW - chance KW - kurth KW - nearinfrared KW - nirs KW - piglet KW - review AU - Kurth, Dean AU - Steven, JM AU - Benaron, D AU - Chance, B PY - 1992/10/11/ UR - http://dx.doi.org/10.1007/BF01617023 ER -