Regional distribution of cerebral blood volume and cerebral blood flow in newborn piglets--effect of hypoxia/hypercapnia Export

@article{citeulike:3283620, abstract = {The relationship between regional parenchymal cerebral blood volume (CBV), regional cerebral blood flow (CBF) and the calculated mean transit time (MTT) was investigated in 14 newborn piglets. The effects of combined hypoxic hypoxia (paO2=32±5 mm Hg) and hypercapnia (paCO2=68±5 mm Hg) were measured in seven animals. Remaining animals served as the control group. During baseline conditions the highest CBF and CVB values were found in the lower brainstem and cerebellum, whereas white matter exhibited the lowest values (p<0.05). MTT was prolonged within the cerebral cortex (2.34±0.42 s-1) compared with the thalamic MTT (1.53±0.38 s-1) (p<0.05). Under moderate hypoxia/hypercapnia, a CBF increase to the forebrain (p<0.05) resulted in an elevated brain oxygen delivery (p<0.05) and so CMRO2 remained unchanged. Moreover, a moderate increase of CBV and a marked shortening of MTT occurred (p<0.05). The CBV increase was higher in structures with lowest baseline values, i.e., thalamus (66\% increase) and white matter (62\% increase) (p<0.05). MTT was between 22\% of baseline in the lower brainstem and 49\% in white matter (p<0.05). We conclude that under normoxic and normocapnic conditions the newborn piglets exhibit a comparatively enlarged intraparenchymal CBV. Moderate hypoxia and hypercapnia induced a marked increase in cerebral blood flow which appears to be caused by an increased perfusion velocity, expressed by a strongly reduced mean transit time and by a concomitant CBV increase.}, author = {Bauer, Reinhard and Bergmann, Ralf and Walter, Bernd and Brust, Peter and Zwiener, Ullrich and Johannsen, Bernd}, citeulike-article-id = {3283620}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0165-3806(98)00167-9}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6SYW-3VH80XN-9/2/bce6ce7312b76b7b4732d20bcd393ca4}, day = {11}, doi = {10.1016/S0165-3806(98)00167-9}, journal = {Developmental Brain Research}, keywords = {blood, cbf, cbv, flow, hypercapnia, hypoxia, neonate, newborn, piglet}, month = {January}, number = {1}, pages = {89--98}, posted-at = {2008-09-18 03:31:23}, priority = {2}, title = {Regional distribution of cerebral blood volume and cerebral blood flow in newborn piglets--effect of hypoxia/hypercapnia}, url = {http://dx.doi.org/10.1016/S0165-3806(98)00167-9}, volume = {112}, year = {1999} }

TY - JOUR ID - citeulike:3283620 L3 - citeulike-article-id:3283620 N2 - The relationship between regional parenchymal cerebral blood volume (CBV), regional cerebral blood flow (CBF) and the calculated mean transit time (MTT) was investigated in 14 newborn piglets. The effects of combined hypoxic hypoxia (paO2=32±5 mm Hg) and hypercapnia (paCO2=68±5 mm Hg) were measured in seven animals. Remaining animals served as the control group. During baseline conditions the highest CBF and CVB values were found in the lower brainstem and cerebellum, whereas white matter exhibited the lowest values (p<0.05). MTT was prolonged within the cerebral cortex (2.34±0.42 s-1) compared with the thalamic MTT (1.53±0.38 s-1) (p<0.05). Under moderate hypoxia/hypercapnia, a CBF increase to the forebrain (p<0.05) resulted in an elevated brain oxygen delivery (p<0.05) and so CMRO2 remained unchanged. Moreover, a moderate increase of CBV and a marked shortening of MTT occurred (p<0.05). The CBV increase was higher in structures with lowest baseline values, i.e., thalamus (66% increase) and white matter (62% increase) (p<0.05). MTT was between 22% of baseline in the lower brainstem and 49% in white matter (p<0.05). We conclude that under normoxic and normocapnic conditions the newborn piglets exhibit a comparatively enlarged intraparenchymal CBV. Moderate hypoxia and hypercapnia induced a marked increase in cerebral blood flow which appears to be caused by an increased perfusion velocity, expressed by a strongly reduced mean transit time and by a concomitant CBV increase. IS - 1 JF - Developmental Brain Research EP - 98 TI - Regional distribution of cerebral blood volume and cerebral blood flow in newborn piglets--effect of hypoxia/hypercapnia VL - 112 SP - 89 KW - blood KW - cbf KW - cbv KW - flow KW - hypercapnia KW - hypoxia KW - neonate KW - newborn KW - piglet AU - Bauer, Reinhard AU - Bergmann, Ralf AU - Walter, Bernd AU - Brust, Peter AU - Zwiener, Ullrich AU - Johannsen, Bernd PY - 1999/01/11/ UR - http://dx.doi.org/10.1016/S0165-3806(98)00167-9 ER -