Pediatric perfusion imaging using pulsed arterial spin labeling Export

@article{citeulike:3790322, abstract = {To test the feasibility of pediatric perfusion imaging using a pulsed arterial spin labeling (ASL) technique at 1.5 T.ASL perfusion imaging was carried out on seven neurologically normal children and five healthy adults. The signal-to-noise ratio (SNR) of the perfusion images along with T1, M0, arterial transit time, and the temporal fluctuation of the ASL image series were measured and compared between the two age groups. In addition, ASL perfusion magnetic resonance (MR) was performed on three children with neurologic disorder.In the cohort of neurologically normal children, a 70\% increase in the SNR of the ASL perfusion images and a 30\% increase in the absolute cerebral blood flow compared to the adult data were observed. The measures of ASL SNR, T1, and M0 were found to decrease linearly with age. Transit time and temporal fluctuation of the ASL perfusion image series were not significantly different between the two age groups. The feasibility of ASL in the diagnosis of pediatric neurologic disease was also illustrated.ASL is a promising tool for pediatric perfusion imaging given the unique and reciprocal benefits in terms of safety and image quality. J. Magn. Reson. Imaging 2003;18:404-413. {\copyright} 2003 Wiley-Liss, Inc.}, address = {Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Child Neurology, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; VA Medical Center, University of California-San Francisco, San Francisco, California; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Radiology, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania}, author = {Wang, Jiongjiong and Licht, Daniel J. and Jahng, Geon-Ho and Liu, Chia-Shang and Rubin, Joan T. and Haselgrove, John and Zimmerman, Robert A. and Detre, John A.}, citeulike-article-id = {3790322}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/jmri.10372}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/105557019/ABSTRACT}, doi = {10.1002/jmri.10372}, journal = {Journal of Magnetic Resonance Imaging}, keywords = {eylembibtex}, number = {4}, pages = {404--413}, posted-at = {2008-12-15 22:06:25}, priority = {2}, title = {Pediatric perfusion imaging using pulsed arterial spin labeling}, url = {http://dx.doi.org/10.1002/jmri.10372}, volume = {18}, year = {2003} }

TY - JOUR ID - citeulike:3790322 L3 - citeulike-article-id:3790322 N2 - To test the feasibility of pediatric perfusion imaging using a pulsed arterial spin labeling (ASL) technique at 1.5 T.ASL perfusion imaging was carried out on seven neurologically normal children and five healthy adults. The signal-to-noise ratio (SNR) of the perfusion images along with T1, M0, arterial transit time, and the temporal fluctuation of the ASL image series were measured and compared between the two age groups. In addition, ASL perfusion magnetic resonance (MR) was performed on three children with neurologic disorder.In the cohort of neurologically normal children, a 70% increase in the SNR of the ASL perfusion images and a 30% increase in the absolute cerebral blood flow compared to the adult data were observed. The measures of ASL SNR, T1, and M0 were found to decrease linearly with age. Transit time and temporal fluctuation of the ASL perfusion image series were not significantly different between the two age groups. The feasibility of ASL in the diagnosis of pediatric neurologic disease was also illustrated.ASL is a promising tool for pediatric perfusion imaging given the unique and reciprocal benefits in terms of safety and image quality. J. Magn. Reson. Imaging 2003;18:404-413. © 2003 Wiley-Liss, Inc. IS - 4 JF - Journal of Magnetic Resonance Imaging AD - Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Child Neurology, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; VA Medical Center, University of California-San Francisco, San Francisco, California; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Radiology, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania EP - 413 TI - Pediatric perfusion imaging using pulsed arterial spin labeling VL - 18 SP - 404 KW - eylembibtex AU - Wang, Jiongjiong AU - Licht, Daniel AU - Jahng, Geon-Ho AU - Liu, Chia-Shang AU - Rubin, Joan AU - Haselgrove, John AU - Zimmerman, Robert AU - Detre, John PY - 2003/// UR - http://dx.doi.org/10.1002/jmri.10372 ER -