Fluctuations in Mass-Action Equilibrium of Protein Binding Networks Export

@article{citeulike:3843368, abstract = {We consider two types of fluctuations in the mass-action equilibrium in protein binding networks. The first type is driven by slow changes in total concentrations of interacting proteins. The second type (spontaneous) is caused by quickly decaying thermodynamic deviations away from equilibrium. We investigate the effects of network connectivity on fluctuations by comparing them to scenarios in which the interacting pair is isolated from the network and analytically derives bounds on fluctuations. Collective effects are shown to sometimes lead to large amplification of spontaneous fluctuations. The strength of both types of fluctuations is positively correlated with the complex connectivity and negatively correlated with complex concentration. Our general findings are illustrated using a curated network of protein interactions and multiprotein complexes in baker's yeast, with empirical protein concentrations.}, author = {Yan, Koon K. and Walker, Dylan and Maslov, Sergei}, citeulike-article-id = {3843368}, citeulike-linkout-0 = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PRLTAO000101000026268102000001&idtype=cvips&gifs=yes}, citeulike-linkout-1 = {http://link.aps.org/abstract/PRL/v101/e268102}, journal = {Physical Review Letters}, keywords = {biochemical\_noise, dylan\_walker, fluctuationdissipationtheorem, fluctuations, law\_of\_mass\_action, ppi, protein\_binding\_networks, protein\_interaction\_networks}, number = {26}, posted-at = {2009-06-17 17:58:11}, priority = {0}, publisher = {APS}, title = {Fluctuations in Mass-Action Equilibrium of Protein Binding Networks}, url = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PRLTAO000101000026268102000001&idtype=cvips&gifs=yes}, volume = {101}, year = {2008} }

TY - JOUR ID - citeulike:3843368 L3 - citeulike-article-id:3843368 N2 - We consider two types of fluctuations in the mass-action equilibrium in protein binding networks. The first type is driven by slow changes in total concentrations of interacting proteins. The second type (spontaneous) is caused by quickly decaying thermodynamic deviations away from equilibrium. We investigate the effects of network connectivity on fluctuations by comparing them to scenarios in which the interacting pair is isolated from the network and analytically derives bounds on fluctuations. Collective effects are shown to sometimes lead to large amplification of spontaneous fluctuations. The strength of both types of fluctuations is positively correlated with the complex connectivity and negatively correlated with complex concentration. Our general findings are illustrated using a curated network of protein interactions and multiprotein complexes in baker's yeast, with empirical protein concentrations. IS - 26 JF - Physical Review Letters TI - Fluctuations in Mass-Action Equilibrium of Protein Binding Networks PB - APS VL - 101 KW - biochemical_noise KW - dylan_walker KW - fluctuationdissipationtheorem KW - fluctuations KW - law_of_mass_action KW - ppi KW - protein_binding_networks KW - protein_interaction_networks AU - Yan, Koon AU - Walker, Dylan AU - Maslov, Sergei PY - 2008/// UR - http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PRLTAO000101000026268102000001&idtype=cvips&gifs=yes ER -