The promises and pitfalls of RNA-interference-based therapeutics Export

@article{citeulike:3923100, abstract = {The discovery that gene expression can be controlled by the Watson\&\#19;Crick base-pairing of small RNAs with messenger RNAs containing complementary sequence \&\#20; a process known as RNA interference \&\#20; has markedly advanced our understanding of eukaryotic gene regulation and function. The ability of short RNA}, author = {Castanotto, Daniela and Rossi, John J.}, citeulike-article-id = {3923100}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature07758}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature07758}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19158789}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19158789}, day = {21}, doi = {10.1038/nature07758}, issn = {0028-0836}, journal = {Nature}, keywords = {microrna, review, rnai, silencing, sirna, therapy}, month = {January}, number = {7228}, pages = {426--433}, posted-at = {2009-01-28 18:27:27}, priority = {0}, publisher = {Nature Publishing Group}, title = {The promises and pitfalls of RNA-interference-based therapeutics}, url = {http://dx.doi.org/10.1038/nature07758}, volume = {457}, year = {2009} }

TY - JOUR ID - citeulike:3923100 L3 - citeulike-article-id:3923100 N2 - The discovery that gene expression can be controlled by the WatsonCrick base-pairing of small RNAs with messenger RNAs containing complementary sequence  a process known as RNA interference  has markedly advanced our understanding of eukaryotic gene regulation and function. The ability of short RNA IS - 7228 JF - Nature SN - 0028-0836 EP - 433 TI - The promises and pitfalls of RNA-interference-based therapeutics PB - Nature Publishing Group VL - 457 SP - 426 KW - microrna KW - review KW - rnai KW - silencing KW - sirna KW - therapy AU - Castanotto, Daniela AU - Rossi, John PY - 2009/01/21/ UR - http://dx.doi.org/10.1038/nature07758 ER -