MicroRNAs in Cancer Export

by: Ramiro Garzon, George A. Calin, Carlo M. Croce

Annual Review of Medicine, Vol. 60, No. 1. (2009), pp. 167-179.

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aberration cancer human microrna review

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Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.

@article{citeulike:4115920, abstract = {MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.}, author = {Garzon, Ramiro and Calin, George A. and Croce, Carlo M.}, citeulike-article-id = {4115920}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.med.59.053006.104707}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.med.59.053006.104707}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19630570}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19630570}, doi = {10.1146/annurev.med.59.053006.104707}, issn = {1545-326X}, journal = {Annual Review of Medicine}, keywords = {aberration, cancer, human, microrna, review}, number = {1}, pages = {167--179}, posted-at = {2009-07-29 10:52:08}, priority = {2}, title = {MicroRNAs in Cancer}, url = {http://dx.doi.org/10.1146/annurev.med.59.053006.104707}, volume = {60}, year = {2009} }

RIS record

TY - JOUR ID - citeulike:4115920 L3 - citeulike-article-id:4115920 N2 - MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer. IS - 1 JF - Annual Review of Medicine SN - 1545-326X EP - 179 TI - MicroRNAs in Cancer VL - 60 SP - 167 KW - aberration KW - cancer KW - human KW - microrna KW - review AU - Garzon, Ramiro AU - Calin, George AU - Croce, Carlo PY - 2009/// UR - http://dx.doi.org/10.1146/annurev.med.59.053006.104707 ER -

MicroRNAs in Cancer Export

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