Causes and consequences of microRNA dysregulation in cancer Export

@article{citeulike:5804714, abstract = {Over the past several years it has become clear that alterations in the expression of microRNA (miRNA) genes contribute to the pathogenesis of most — if not all — human malignancies. These alterations can be caused by various mechanisms, including deletions, amplifications or mutations involving miRNA loci, epigenetic silencing or the dysregulation of transcription factors that target specific miRNAs. Because malignant cells show dependence on the dysregulated expression of miRNA genes, which in turn control or are controlled by the dysregulation of multiple protein-coding oncogenes or tumour suppressor genes, these small RNAs provide important opportunities for the development of future miRNA-based therapies.}, author = {Croce, Carlo M.}, citeulike-article-id = {5804714}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2634}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2634}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19763153}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19763153}, day = {01}, doi = {10.1038/nrg2634}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, keywords = {cancer, dysregulation, microrna, review}, month = {October}, number = {10}, pages = {704--714}, posted-at = {2009-09-21 10:56:20}, priority = {2}, publisher = {Nature Publishing Group}, title = {Causes and consequences of microRNA dysregulation in cancer}, url = {http://dx.doi.org/10.1038/nrg2634}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5804714 L3 - citeulike-article-id:5804714 N2 - Over the past several years it has become clear that alterations in the expression of microRNA (miRNA) genes contribute to the pathogenesis of most — if not all — human malignancies. These alterations can be caused by various mechanisms, including deletions, amplifications or mutations involving miRNA loci, epigenetic silencing or the dysregulation of transcription factors that target specific miRNAs. Because malignant cells show dependence on the dysregulated expression of miRNA genes, which in turn control or are controlled by the dysregulation of multiple protein-coding oncogenes or tumour suppressor genes, these small RNAs provide important opportunities for the development of future miRNA-based therapies. IS - 10 JF - Nature Reviews Genetics SN - 1471-0056 EP - 714 TI - Causes and consequences of microRNA dysregulation in cancer PB - Nature Publishing Group VL - 10 SP - 704 KW - cancer KW - dysregulation KW - microrna KW - review AU - Croce, Carlo PY - 2009/10/01/ UR - http://dx.doi.org/10.1038/nrg2634 ER -