Molecular dynamics simulation of a palmitoyl-oleoyl phosphatidylserine bilayer with Na+ counterions and NaCl. Export

@article{citeulike:988216, abstract = {Two 40 ns molecular dynamics simulations of a palmitoyl-oleoyl phosphatidylserine (POPS) lipid bilayer in the liquid crystalline phase with Na(+) counterions and NaCl were carried out to investigate the structure of the negatively charged lipid bilayer and the effect of salt (NaCl) on the lipid bilayer structure. Na(+) ions were found to penetrate deep into the ester region of the water/lipid interface of the bilayer. Interaction of the Na(+) ions with the lipid bilayer is accompanied by a loss of water molecules around the ion and a simultaneous increase in the number of ester carbonyl oxygen atoms binding the ion, which define an octahedral and square pyramidal geometry. The amine group of the lipid molecule is involved in the formation of inter- and intramolecular hydrogen bonds with the carboxylate and the phosphodiester groups of the lipid molecule. The area per lipid of the POPS bilayer is unaffected by the presence of 0.15M NaCl. There is a small increase in the order parameter of carbon atoms in the beginning of the alkyl chain in the presence of NaCl. This is due to a greater number of Na(+) ions being coordinated by the ester carbonyl oxygen atoms in the water/lipid interface region of the POPS bilayer.}, address = {Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada.}, author = {Mukhopadhyay, P. and Monticelli, L. and Tieleman, D. P.}, citeulike-article-id = {988216}, citeulike-linkout-0 = {http://www.biophysj.org/cgi/content/abstract/86/3/1601}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14990486}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14990486}, issn = {0006-3495}, journal = {Biophys J}, keywords = {membrane}, month = {March}, number = {3}, pages = {1601--1609}, posted-at = {2008-04-10 14:37:16}, priority = {2}, title = {Molecular dynamics simulation of a palmitoyl-oleoyl phosphatidylserine bilayer with Na+ counterions and NaCl.}, url = {http://www.biophysj.org/cgi/content/abstract/86/3/1601}, volume = {86}, year = {2004} }

TY - JOUR ID - citeulike:988216 L3 - citeulike-article-id:988216 N2 - Two 40 ns molecular dynamics simulations of a palmitoyl-oleoyl phosphatidylserine (POPS) lipid bilayer in the liquid crystalline phase with Na(+) counterions and NaCl were carried out to investigate the structure of the negatively charged lipid bilayer and the effect of salt (NaCl) on the lipid bilayer structure. Na(+) ions were found to penetrate deep into the ester region of the water/lipid interface of the bilayer. Interaction of the Na(+) ions with the lipid bilayer is accompanied by a loss of water molecules around the ion and a simultaneous increase in the number of ester carbonyl oxygen atoms binding the ion, which define an octahedral and square pyramidal geometry. The amine group of the lipid molecule is involved in the formation of inter- and intramolecular hydrogen bonds with the carboxylate and the phosphodiester groups of the lipid molecule. The area per lipid of the POPS bilayer is unaffected by the presence of 0.15M NaCl. There is a small increase in the order parameter of carbon atoms in the beginning of the alkyl chain in the presence of NaCl. This is due to a greater number of Na(+) ions being coordinated by the ester carbonyl oxygen atoms in the water/lipid interface region of the POPS bilayer. IS - 3 JF - Biophys J SN - 0006-3495 AD - Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada. EP - 1609 TI - Molecular dynamics simulation of a palmitoyl-oleoyl phosphatidylserine bilayer with Na+ counterions and NaCl. VL - 86 SP - 1601 KW - membrane AU - Mukhopadhyay, P AU - Monticelli, L AU - Tieleman, DP PY - 2004/03// UR - http://www.biophysj.org/cgi/content/abstract/86/3/1601 ER -