Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin. Export

@article{citeulike:4363737, abstract = {Quercetin, a naturally occurring bioflavonoid inhibited the activities of phosphorylase kinase and a partially purified tyrosine protein kinase from rat lung. The inhibition was rapid and concentration dependent. Quercetin at 100 microM inhibited the activities of phosphorylase kinase and tyrosine protein kinase by about 95 and 80-90 percent respectively. ATP reversed the quercetin mediated inhibition of tyrosine protein kinase but not of phosphorylase kinase. These data suggest that quercetin has differential effect on different protein kinase activities and it may be used as a tool to probe the role of various protein kinases in cell function.}, author = {Srivastava, A. K.}, citeulike-article-id = {4363737}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/4041183}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=4041183}, day = {30}, issn = {0006-291X}, journal = {Biochemical and biophysical research communications}, keywords = {quercetin}, month = {August}, number = {1}, pages = {1--5}, posted-at = {2009-04-18 22:18:38}, priority = {2}, title = {Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/4041183}, volume = {131}, year = {1985} }

TY - JOUR ID - citeulike:4363737 L3 - citeulike-article-id:4363737 N2 - Quercetin, a naturally occurring bioflavonoid inhibited the activities of phosphorylase kinase and a partially purified tyrosine protein kinase from rat lung. The inhibition was rapid and concentration dependent. Quercetin at 100 microM inhibited the activities of phosphorylase kinase and tyrosine protein kinase by about 95 and 80-90 percent respectively. ATP reversed the quercetin mediated inhibition of tyrosine protein kinase but not of phosphorylase kinase. These data suggest that quercetin has differential effect on different protein kinase activities and it may be used as a tool to probe the role of various protein kinases in cell function. IS - 1 JF - Biochemical and biophysical research communications SN - 0006-291X EP - 5 TI - Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin. VL - 131 SP - 1 KW - quercetin AU - Srivastava, AK PY - 1985/08/30/ UR - http://view.ncbi.nlm.nih.gov/pubmed/4041183 ER -