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[Epigenetics and colorectal cancer].

by: Pablo Menéndez, Pedro Villarejo, David Padilla, José María M. Menéndez, José Antonio A. Rodríguez Montes
Cirugía española, Vol. 90, No. 5. (May 2012), pp. 277-283, doi:10.1016/j.ciresp.2011.11.006  Key: citeulike:12028237

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Abstract

The epigenetic and physiological mechanisms that alter the structure of chromatin include the methylation of DNA, changes in the histones, and changes in RNA. A literature review has been carried out using PubMed on the evidence published on the association between epigenetics and colorectal cancer. The scientific literature shows that epigenetic changes, such as genetic modifications may be very significant in the origin of neoplastic disease, contributing both to the development and progression of the disease. Copyright © 2011 AEC. Published by Elsevier Espana. All rights reserved.


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