Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine via the Group C protocol mechanism of the National Cancer Institute: a report of 979 patients. Export

@article{citeulike:4065958, abstract = {PURPOSE: To provide cladribine (CdA) to physicians for the treatment of patients with previously treated or untreated hairy cell leukemia (HCL), and to determine the response rate, response duration, survival, and toxicity with this agent. PATIENTS AND METHODS: This Group C phase II study was open to all eligible patients whose primary physician obtained written permission from the National Cancer Institute (NCI) to register patients onto this protocol. Of 979 patients registered, 861 were assessable for response and 895 for toxicity. RESULTS: The complete remission (CR) rate was 50\% and the partial remission (PR) rate was 37\%. At a median follow-up of 52 months, 12\% of patients were reported to have progressed and 62 (7\%) have died of disease. CONCLUSION: This large experience confirms the excellent response rates and remission duration of CdA in patients with HCL. Nevertheless, the response rates in this setting, which approximates general clinical practice, were lower than in other series. In general, CdA was well tolerated, but the potential increased risk for secondary malignancies requires additional follow-up evaluation. CdA can now be considered as one of the best agents for the treatment of HCL.}, author = {Cheson, B. D. and Sorensen, J. M. and Vena, D. A. and Montello, M. J. and Barrett, J. A. and Damasio, E. and Tallman, M. and Annino, L. and Connors, J. and Coiffier, B. and Lauria, F.}, citeulike-article-id = {4065958}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9738569}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9738569}, issn = {0732-183X}, journal = {Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, keywords = {cell, hairy, hcl, leukemia}, month = {September}, number = {9}, pages = {3007--3015}, posted-at = {2009-02-17 21:47:33}, priority = {2}, title = {Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine via the Group C protocol mechanism of the National Cancer Institute: a report of 979 patients.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9738569}, volume = {16}, year = {1998} }

TY - JOUR ID - citeulike:4065958 L3 - citeulike-article-id:4065958 N2 - PURPOSE: To provide cladribine (CdA) to physicians for the treatment of patients with previously treated or untreated hairy cell leukemia (HCL), and to determine the response rate, response duration, survival, and toxicity with this agent. PATIENTS AND METHODS: This Group C phase II study was open to all eligible patients whose primary physician obtained written permission from the National Cancer Institute (NCI) to register patients onto this protocol. Of 979 patients registered, 861 were assessable for response and 895 for toxicity. RESULTS: The complete remission (CR) rate was 50% and the partial remission (PR) rate was 37%. At a median follow-up of 52 months, 12% of patients were reported to have progressed and 62 (7%) have died of disease. CONCLUSION: This large experience confirms the excellent response rates and remission duration of CdA in patients with HCL. Nevertheless, the response rates in this setting, which approximates general clinical practice, were lower than in other series. In general, CdA was well tolerated, but the potential increased risk for secondary malignancies requires additional follow-up evaluation. CdA can now be considered as one of the best agents for the treatment of HCL. IS - 9 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology SN - 0732-183X EP - 3015 TI - Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine via the Group C protocol mechanism of the National Cancer Institute: a report of 979 patients. VL - 16 SP - 3007 KW - cell KW - hairy KW - hcl KW - leukemia AU - Cheson, BD AU - Sorensen, JM AU - Vena, DA AU - Montello, MJ AU - Barrett, JA AU - Damasio, E AU - Tallman, M AU - Annino, L AU - Connors, J AU - Coiffier, B AU - Lauria, F PY - 1998/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/9738569 ER -