Neuropsychiatric applications of DTI - a review.

@article{Lim2002, abstract = {Psychiatric disorders are common throughout the world and are a leading cause of disability. There is a growing appreciation of the importance of connectivity to brain function. Disruption of this connectivity can result in brain dysfunction manifested in impaired cognitive functioning and the development of clinical symptoms. White matter forms the basis of anatomical connectivity. Diffusion tensor imaging (DTI) is a useful tool for examining and quantifying white matter microstructure. Clinical research studies in alcoholism, HIV-1 infection, geriatric depression and schizophrenia using DTI have revealed abnormalities in white matter microstructure. The use of complementary imaging methods may be helpful in further characterizing these abnormalities. Other psychiatric disorders may also have white matter involvement amenable to study with DTI. Advances in acquisition and analysis methods will be necessary to further advance work in this field. The study of animal models and postmortem tissue may be helpful in elucidating the neurobiological underpinnings of abnormalities observed with DTI.}, address = {Department of Psychiatry, University of Minnesota, Minneapolis 55454, USA. kolim@umn.edu}, author = {Lim, K. O. and Helpern, J. A. }, citeulike-article-id = {2625875}, doi = {10.1002/nbm.789}, issn = {0952-3480}, journal = {NMR in biomedicine}, number = {7-8}, pages = {587--593}, posted-at = {2008-04-03 12:52:21}, priority = {2}, title = {Neuropsychiatric applications of DTI - a review.}, url = {http://dx.doi.org/10.1002/nbm.789}, volume = {15}, year = {2002} }

TY - JOUR ID - Lim2002 L3 - citeulike-article-id:2625875 TI - Neuropsychiatric applications of DTI - a review. JF - NMR in biomedicine VL - 15 IS - 7-8 SP - 587 EP - 593 AD - Department of Psychiatry, University of Minnesota, Minneapolis 55454, USA. kolim@umn.edu SN - 0952-3480 N2 - Psychiatric disorders are common throughout the world and are a leading cause of disability. There is a growing appreciation of the importance of connectivity to brain function. Disruption of this connectivity can result in brain dysfunction manifested in impaired cognitive functioning and the development of clinical symptoms. White matter forms the basis of anatomical connectivity. Diffusion tensor imaging (DTI) is a useful tool for examining and quantifying white matter microstructure. Clinical research studies in alcoholism, HIV-1 infection, geriatric depression and schizophrenia using DTI have revealed abnormalities in white matter microstructure. The use of complementary imaging methods may be helpful in further characterizing these abnormalities. Other psychiatric disorders may also have white matter involvement amenable to study with DTI. Advances in acquisition and analysis methods will be necessary to further advance work in this field. The study of animal models and postmortem tissue may be helpful in elucidating the neurobiological underpinnings of abnormalities observed with DTI. AU - Lim, KO AU - Helpern, JA PY - 2002///c UR - http://dx.doi.org/10.1002/nbm.789 ER -