The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. Export

@article{citeulike:1325084, abstract = {The initial step in a humoral immune response involves the acquisition of antigens by B cells via surface immunoglobulin. Surprisingly, anatomic studies indicate that lymph-borne proteins do not have access to the follicles where naive B cells reside. Thus, it is unclear how B cells acquire antigens that drain to lymph nodes. By tracking a fluorescent antigen and a peptide:MHC II complex derived from it, we show that antigen-specific B cells residing in the follicles acquire antigen within minutes of injection, first in the region closest to the subcapsular sinus where lymph enters the lymph node. Antigen acquisition, presentation, and subsequent T cell-dependent activation did not require B cell migration through the T cell area or exposure to dendritic cells. These results indicate that the humoral response is initiated as soluble antigens diffuse directly from lymph in the subcapsular sinus to be acquired by antigen-specific B cells in the underlying follicles.}, address = {Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. papex001@umn.edu}, author = {Pape, K. A. and Catron, D. M. and Itano, A. A. and Jenkins, M. K.}, citeulike-article-id = {1325084}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2007.02.011}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17379546}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17379546}, doi = {10.1016/j.immuni.2007.02.011}, issn = {1074-7613}, journal = {Immunity}, keywords = {antigen-uptake}, month = {April}, number = {4}, pages = {491--502}, posted-at = {2007-05-24 14:14:13}, priority = {2}, title = {The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles.}, url = {http://dx.doi.org/10.1016/j.immuni.2007.02.011}, volume = {26}, year = {2007} }

TY - JOUR ID - citeulike:1325084 L3 - citeulike-article-id:1325084 N2 - The initial step in a humoral immune response involves the acquisition of antigens by B cells via surface immunoglobulin. Surprisingly, anatomic studies indicate that lymph-borne proteins do not have access to the follicles where naive B cells reside. Thus, it is unclear how B cells acquire antigens that drain to lymph nodes. By tracking a fluorescent antigen and a peptide:MHC II complex derived from it, we show that antigen-specific B cells residing in the follicles acquire antigen within minutes of injection, first in the region closest to the subcapsular sinus where lymph enters the lymph node. Antigen acquisition, presentation, and subsequent T cell-dependent activation did not require B cell migration through the T cell area or exposure to dendritic cells. These results indicate that the humoral response is initiated as soluble antigens diffuse directly from lymph in the subcapsular sinus to be acquired by antigen-specific B cells in the underlying follicles. IS - 4 JF - Immunity SN - 1074-7613 AD - Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. papex001@umn.edu EP - 502 TI - The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. VL - 26 SP - 491 KW - antigen-uptake AU - Pape, KA AU - Catron, DM AU - Itano, AA AU - Jenkins, MK PY - 2007/04// UR - http://dx.doi.org/10.1016/j.immuni.2007.02.011 ER -