The Genomic Landscapes of Human Breast and Colorectal Cancers. Export

@article{citeulike:1812438, abstract = {Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.}, address = {The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.}, author = {Wood, Laura D D. and Parsons, D Williams W. and Jones, Si\^{a}n and Lin, Jimmy and Sj\"{o}blom, Tobias and Leary, Rebecca J J. and Shen, Dong and Boca, Simina M M. and Barber, Thomas and Ptak, Janine and Silliman, Natalie and Szabo, Steve and Dezso, Zoltan and Ustyanksky, Vadim and Nikolskaya, Tatiana and Nikolsky, Yuri and Karchin, Rachel and Wilson, Paul A A. and Kaminker, Joshua S S. and Zhang, Zemin and Croshaw, Randal and Willis, Joseph and Dawson, Dawn and Shipitsin, Michail and Willson, James K V K. and Sukumar, Saraswati and Polyak, Kornelia and Park, Ben Ho H. and Pethiyagoda, Charit L L. and Pant, P V Krishna V. and Ballinger, Dennis G G. and Sparks, Andrew B B. and Hartigan, James and Smith, Douglas R R. and Suh, Erick and Papadopoulos, Nickolas and Buckhaults, Phillip and Markowitz, Sanford D D. and Parmigiani, Giovanni and Kinzler, Kenneth W W. and Velculescu, Victor E E. and Vogelstein, Bert}, citeulike-article-id = {1812438}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1145720}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/318/5853/1108}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17932254}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17932254}, day = {11}, doi = {10.1126/science.1145720}, issn = {1095-9203}, journal = {Science}, keywords = {antigen, breast, colon, mutation, tumor}, month = {October}, posted-at = {2008-04-21 10:39:46}, priority = {2}, title = {The Genomic Landscapes of Human Breast and Colorectal Cancers.}, url = {http://dx.doi.org/10.1126/science.1145720}, year = {2007} }

TY - JOUR ID - citeulike:1812438 L3 - citeulike-article-id:1812438 N2 - Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy. JF - Science SN - 1095-9203 AD - The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA. TI - The Genomic Landscapes of Human Breast and Colorectal Cancers. KW - antigen KW - breast KW - colon KW - mutation KW - tumor AU - Wood, Laura D AU - Parsons, D Williams AU - Jones, Siân AU - Lin, Jimmy AU - Sjöblom, Tobias AU - Leary, Rebecca J AU - Shen, Dong AU - Boca, Simina M AU - Barber, Thomas AU - Ptak, Janine AU - Silliman, Natalie AU - Szabo, Steve AU - Dezso, Zoltan AU - Ustyanksky, Vadim AU - Nikolskaya, Tatiana AU - Nikolsky, Yuri AU - Karchin, Rachel AU - Wilson, Paul A AU - Kaminker, Joshua S AU - Zhang, Zemin AU - Croshaw, Randal AU - Willis, Joseph AU - Dawson, Dawn AU - Shipitsin, Michail AU - Willson, James K V AU - Sukumar, Saraswati AU - Polyak, Kornelia AU - Park, Ben Ho AU - Pethiyagoda, Charit L AU - Pant, P V Krishna AU - Ballinger, Dennis G AU - Sparks, Andrew B AU - Hartigan, James AU - Smith, Douglas R AU - Suh, Erick AU - Papadopoulos, Nickolas AU - Buckhaults, Phillip AU - Markowitz, Sanford D AU - Parmigiani, Giovanni AU - Kinzler, Kenneth W AU - Velculescu, Victor E AU - Vogelstein, Bert PY - 2007/10/11/ UR - http://dx.doi.org/10.1126/science.1145720 ER -