The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD. Export

@article{citeulike:1937112, abstract = {Members of the BCL-2 gene family are well known for their role in the pathogenesis of B-cell lymphomas in humans and in mouse models. A recent report that knockout mice deficient for the proapoptotic BCL-2 family member gene BAD frequently develop B-cell lymphomas prompted us to analyze a large collection of human B-cell lymphomas for inactivating mutations in the BAD gene. All 3 exons of the BAD gene were amplified and directly sequenced. The 81 lymphomas analyzed included 16 cases of B-cell chronic lymphocytic leukemia, 11 mantle-cell lymphomas, 10 follicular lymphomas, 7 MALT lymphomas, 8 Burkitt's lymphoma cell lines, 3 cell lines of multiple myeloma, 15 cases and 4 cell lines of diffuse large B-cell lymphoma and 7 Hodgkin's lymphoma lines. No mutations were found in any of the cases. We conclude that mutations in the BAD gene do not play a role in the pathogenesis of the major subtypes of human B-cell lymphomas.}, address = {Institute for Cell Biology (Tumor Research), University of Duisburg-Essen, Medical School, Essen, Germany. roland.schmitz@uni-essen.de}, author = {Schmitz, R. and Thomas, R. K. and Harttrampf, A. C. and Wickenhauser, C. and Schultze, J. L. and Hansmann, M. L. and Wolf, J. and K\"{u}ppers, R.}, citeulike-article-id = {1937112}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/ijc.22010}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16646081}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16646081}, day = {1}, doi = {10.1002/ijc.22010}, issn = {0020-7136}, journal = {Int J Cancer}, keywords = {bad, bcl-2, myeloma}, month = {October}, number = {7}, pages = {1738--1740}, posted-at = {2007-11-19 09:25:11}, priority = {2}, title = {The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD.}, url = {http://dx.doi.org/10.1002/ijc.22010}, volume = {119}, year = {2006} }

TY - JOUR ID - citeulike:1937112 L3 - citeulike-article-id:1937112 N2 - Members of the BCL-2 gene family are well known for their role in the pathogenesis of B-cell lymphomas in humans and in mouse models. A recent report that knockout mice deficient for the proapoptotic BCL-2 family member gene BAD frequently develop B-cell lymphomas prompted us to analyze a large collection of human B-cell lymphomas for inactivating mutations in the BAD gene. All 3 exons of the BAD gene were amplified and directly sequenced. The 81 lymphomas analyzed included 16 cases of B-cell chronic lymphocytic leukemia, 11 mantle-cell lymphomas, 10 follicular lymphomas, 7 MALT lymphomas, 8 Burkitt's lymphoma cell lines, 3 cell lines of multiple myeloma, 15 cases and 4 cell lines of diffuse large B-cell lymphoma and 7 Hodgkin's lymphoma lines. No mutations were found in any of the cases. We conclude that mutations in the BAD gene do not play a role in the pathogenesis of the major subtypes of human B-cell lymphomas. IS - 7 JF - Int J Cancer SN - 0020-7136 AD - Institute for Cell Biology (Tumor Research), University of Duisburg-Essen, Medical School, Essen, Germany. roland.schmitz@uni-essen.de EP - 1740 TI - The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD. VL - 119 SP - 1738 KW - bad KW - bcl-2 KW - myeloma AU - Schmitz, R AU - Thomas, RK AU - Harttrampf, AC AU - Wickenhauser, C AU - Schultze, JL AU - Hansmann, ML AU - Wolf, J AU - Küppers, R PY - 2006/10/01/ UR - http://dx.doi.org/10.1002/ijc.22010 ER -