Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Export

@article{citeulike:2438208, abstract = {TNF receptor (TNFR) superfamily members, CD40, and BAFFR play critical roles in B cell survival and differentiation. Genetic deficiency in a novel adaptor molecule, Act1, for CD40 and BAFF results in a dramatic increase in peripheral B cells, which culminates in lymphadenopathy and splenomegaly, hypergammaglobulinemia, and autoantibodies. While the B cell-specific Act1 knockout mice displayed a similar phenotype with less severity, the pathology of the Act1-deficient mice was mostly blocked in CD40-Act1 and BAFF-Act1 double knockout mice. CD40- and BAFF-mediated survival is significantly increased in Act1-deficent B cells, with stronger IkappaB phosphorylation, processing of NF-kappaB2 (p100/p52), and activation of JNK, ERK, and p38 pathways, indicating that Act1 negatively regulates CD40- and BAFF-mediated signaling events. These findings demonstrate that Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling.}, address = {Department of Immunology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.}, author = {Qian, Y. and Qin, J. and Cui, G. and Naramura, M. and Snow, E. C. and Ware, C. F. and Fairchild, R. L. and Omori, S. A. and Rickert, R. C. and Scott, M. and Kotzin, B. L. and Li, X.}, citeulike-article-id = {2438208}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2004.09.001}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15485634}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15485634}, doi = {10.1016/j.immuni.2004.09.001}, issn = {1074-7613}, journal = {Immunity}, keywords = {act1, baff, cd40l}, month = {October}, number = {4}, pages = {575--587}, posted-at = {2008-02-27 19:02:40}, priority = {2}, title = {Act1, a negative regulator in CD40- and BAFF-mediated B cell survival.}, url = {http://dx.doi.org/10.1016/j.immuni.2004.09.001}, volume = {21}, year = {2004} }

TY - JOUR ID - citeulike:2438208 L3 - citeulike-article-id:2438208 N2 - TNF receptor (TNFR) superfamily members, CD40, and BAFFR play critical roles in B cell survival and differentiation. Genetic deficiency in a novel adaptor molecule, Act1, for CD40 and BAFF results in a dramatic increase in peripheral B cells, which culminates in lymphadenopathy and splenomegaly, hypergammaglobulinemia, and autoantibodies. While the B cell-specific Act1 knockout mice displayed a similar phenotype with less severity, the pathology of the Act1-deficient mice was mostly blocked in CD40-Act1 and BAFF-Act1 double knockout mice. CD40- and BAFF-mediated survival is significantly increased in Act1-deficent B cells, with stronger IkappaB phosphorylation, processing of NF-kappaB2 (p100/p52), and activation of JNK, ERK, and p38 pathways, indicating that Act1 negatively regulates CD40- and BAFF-mediated signaling events. These findings demonstrate that Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling. IS - 4 JF - Immunity SN - 1074-7613 AD - Department of Immunology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. EP - 587 TI - Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. VL - 21 SP - 575 KW - act1 KW - baff KW - cd40l AU - Qian, Y AU - Qin, J AU - Cui, G AU - Naramura, M AU - Snow, EC AU - Ware, CF AU - Fairchild, RL AU - Omori, SA AU - Rickert, RC AU - Scott, M AU - Kotzin, BL AU - Li, X PY - 2004/10// UR - http://dx.doi.org/10.1016/j.immuni.2004.09.001 ER -