Report of an International Workshop to Standardize Baseline Evaluation and Response Criteria for Primary CNS Lymphoma

@article{citeulike:2820995, abstract = {Standardized guidelines for the baseline evaluation and response assessment of primary CNS lymphoma (PCNSL) are critical to ensure comparability among clinical trials for newly diagnosed patients. The relative rarity of this tumor precludes rapid completion of large-scale phase III trials and, therefore, our reliance on the results of well-designed phase II trials is critical. To formulate this recommendation, an international group of experts representing hematologic oncology, medical oncology, neuro-oncology, neurology, radiation oncology, neurosurgery, and ophthalmology met to review current standards of reporting and to formulate a consensus opinion regarding minimum baseline evaluation and common standards for assessing response to therapy. The response guidelines were based on the results of neuroimaging, corticosteroid use, ophthalmologic examination, and CSF cytology. A critical issue that requires additional study is the optimal method to assess the neurocognitive impact of therapy and address the quality of life of PCNSL survivors. We hope that these guidelines will improve communication among investigators and comparability among clinical trials in a way that will allow us to develop better therapies for patients. 10.1200/JCO.2005.13.524}, author = {Abrey, Lauren E. and Batchelor, Tracy T. and Ferreri, Andres J. and Gospodarowicz, Mary and Pulczynski, Elisa J. and Zucca, Emanuele and Smith, Justine R. and Korfel, Agnieszka and Soussain, Carole and Deangelis, Lisa M. and Neuwelt, Edward A. and O'Neill, Brian P. and Thiel, Eckhard and Shenkier, Tamara and Graus, Fransesc and van den Bent, Martin and Seymour, John F. and Poortmans, Philip and Armitage, James O. and Cavalli, Franco }, citeulike-article-id = {2820995}, doi = {http://dx.doi.org/10.1200/JCO.2005.13.524}, journal = {J Clin Oncol}, keywords = {pcnsl}, month = {August}, number = {22}, pages = {5034--5043}, posted-at = {2008-05-21 19:25:40}, priority = {2}, title = {Report of an International Workshop to Standardize Baseline Evaluation and Response Criteria for Primary CNS Lymphoma}, url = {http://dx.doi.org/10.1200/JCO.2005.13.524}, volume = {23}, year = {2005} }

TY - JOUR ID - citeulike:2820995 L3 - citeulike-article-id:2820995 TI - Report of an International Workshop to Standardize Baseline Evaluation and Response Criteria for Primary CNS Lymphoma JF - J Clin Oncol VL - 23 IS - 22 SP - 5034 EP - 5043 N2 - Standardized guidelines for the baseline evaluation and response assessment of primary CNS lymphoma (PCNSL) are critical to ensure comparability among clinical trials for newly diagnosed patients. The relative rarity of this tumor precludes rapid completion of large-scale phase III trials and, therefore, our reliance on the results of well-designed phase II trials is critical. To formulate this recommendation, an international group of experts representing hematologic oncology, medical oncology, neuro-oncology, neurology, radiation oncology, neurosurgery, and ophthalmology met to review current standards of reporting and to formulate a consensus opinion regarding minimum baseline evaluation and common standards for assessing response to therapy. The response guidelines were based on the results of neuroimaging, corticosteroid use, ophthalmologic examination, and CSF cytology. A critical issue that requires additional study is the optimal method to assess the neurocognitive impact of therapy and address the quality of life of PCNSL survivors. We hope that these guidelines will improve communication among investigators and comparability among clinical trials in a way that will allow us to develop better therapies for patients. 10.1200/JCO.2005.13.524 KW - pcnsl AU - Abrey, Lauren AU - Batchelor, Tracy AU - Ferreri, Andres AU - Gospodarowicz, Mary AU - Pulczynski, Elisa AU - Zucca, Emanuele AU - Smith, Justine AU - Korfel, Agnieszka AU - Soussain, Carole AU - Deangelis, Lisa AU - Neuwelt, Edward AU - O'Neill, Brian AU - Thiel, Eckhard AU - Shenkier, Tamara AU - Graus, Fransesc AU - van den Bent, Martin AU - Seymour, John AU - Poortmans, Philip AU - Armitage, James AU - Cavalli, Franco PY - 2005/08/01/ UR - http://dx.doi.org/10.1200/JCO.2005.13.524 ER -