Equilibrium between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma Export

@article{citeulike:3129775, abstract = {The growth of solid tumors depends on tumor stroma. A single adoptive transfer of CD8+ CTLs that recognize tumor antigen-loaded stromal cells, but not the cancer cells because of MHC restriction, caused long-term inhibition of tumor growth. T cells persisted and continuously destroyed CD11b+ myeloid-derived, F4/80+ or Gr1+ stromal cells during homeostasis between host and cancer. Using high-affinity T-cell receptor tetramers, we found that both subpopulations of stromal cells captured tumor antigen from surrounding cancer cells. Epitopes on the captured antigen made these cells targets for antigen-specific T cells. These myeloid stromal cells are immunosuppressive, proangiogenic, and phagocytic. Elimination of these myeloid cells allowed T cells to remain active, prevented neovascularization, and prevented tumor resorption so that tumor size remained stationary. These findings show the effectiveness of adoptive CTL therapy directed against tumor stroma and open a new avenue for cancer treatments. [Cancer Res 2008;68(5):1563-71] 10.1158/0008-5472.CAN-07-5324}, author = {Zhang, Bin and Zhang, Yi and Bowerman, Natalie A. and Schietinger, Andrea and Fu, Yang-Xin and Kranz, David M. and Rowley, Donald A. and Schreiber, Hans}, citeulike-article-id = {3129775}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/0008-5472.CAN-07-5324}, citeulike-linkout-1 = {http://cancerres.aacrjournals.org/cgi/content/abstract/68/5/1563}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18316622}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18316622}, day = {1}, doi = {10.1158/0008-5472.CAN-07-5324}, journal = {Cancer Res}, keywords = {angiogenesis}, month = {March}, number = {5}, pages = {1563--1571}, posted-at = {2008-08-17 14:09:11}, priority = {2}, title = {Equilibrium between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma}, url = {http://dx.doi.org/10.1158/0008-5472.CAN-07-5324}, volume = {68}, year = {2008} }

TY - JOUR ID - citeulike:3129775 L3 - citeulike-article-id:3129775 N2 - The growth of solid tumors depends on tumor stroma. A single adoptive transfer of CD8+ CTLs that recognize tumor antigen-loaded stromal cells, but not the cancer cells because of MHC restriction, caused long-term inhibition of tumor growth. T cells persisted and continuously destroyed CD11b+ myeloid-derived, F4/80+ or Gr1+ stromal cells during homeostasis between host and cancer. Using high-affinity T-cell receptor tetramers, we found that both subpopulations of stromal cells captured tumor antigen from surrounding cancer cells. Epitopes on the captured antigen made these cells targets for antigen-specific T cells. These myeloid stromal cells are immunosuppressive, proangiogenic, and phagocytic. Elimination of these myeloid cells allowed T cells to remain active, prevented neovascularization, and prevented tumor resorption so that tumor size remained stationary. These findings show the effectiveness of adoptive CTL therapy directed against tumor stroma and open a new avenue for cancer treatments. [Cancer Res 2008;68(5):1563-71] 10.1158/0008-5472.CAN-07-5324 IS - 5 JF - Cancer Res EP - 1571 TI - Equilibrium between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma VL - 68 SP - 1563 KW - angiogenesis AU - Zhang, Bin AU - Zhang, Yi AU - Bowerman, Natalie AU - Schietinger, Andrea AU - Fu, Yang-Xin AU - Kranz, David AU - Rowley, Donald AU - Schreiber, Hans PY - 2008/03/01/ UR - http://dx.doi.org/10.1158/0008-5472.CAN-07-5324 ER -