Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia. Export

@article{citeulike:3772070, abstract = {BACKGROUND: Adult Burkitt-type lymphoma (BL) and acute lymphoblastic leukemia (B-ALL) are rare entities composing 1\% to 5\% of non-Hodgkin lymphomas NHL) or ALL. Prognosis of BL and B-ALL has been poor with conventional NHL or ALL regimens, but has improved with dose-intensive regimens. METHODS: To evaluate the addition of rituximab, a CD20 monoclonal antibody, to intensive chemotherapy in adults with BL or B-ALL, 31 patients with newly diagnosed BL or B-ALL received the hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) regimen with rituximab. Their median age was 46 years; 29\% were 60 years or older. Rituximab 375 mg/m(2) was given on Days 1 and 11 of hyper-CVAD courses and on Days 1 and 8 of methotrexate and cytarabine courses. RESULTS: Complete remission (complete response [CR]) was achieved in 24 of 28 (86\%) evaluable patients; 3 had a partial response, and 1 had resistant disease. There were no induction deaths. The 3-year overall survival (OS), event-free survival, and disease-free survival rates were 89\%, 80\%, and 88\%, respectively. Nine elderly patients achieved CR with all of them in continuous CR (except 1 death in CR from infection), with a 3-year OS rate of 89\%. Multivariate analysis of current and historical (those treated with hyper-CVAD alone) groups identified age and treatment with rituximab as favorable factors. CONCLUSIONS: The addition of rituximab to hyper-CVAD may improve outcome in adult BL or B-ALL, particularly in elderly patients.}, author = {Thomas, D. A. and Faderl, S. and O'Brien, S. and Bueso-Ramos, C. and Cortes, J. and Garcia-Manero, G. and Giles, F. J. and Verstovsek, S. and Wierda, W. G. and Pierce, S. A. and Shan, J. and Brandt, M. and Hagemeister, F. B. and Keating, M. J. and Cabanillas, F. and Kantarjian, H.}, citeulike-article-id = {3772070}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/cncr.21776}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16502413}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16502413}, day = {1}, doi = {10.1002/cncr.21776}, issn = {0008-543X}, journal = {Cancer}, keywords = {b-all, hypercvad}, month = {April}, number = {7}, pages = {1569--1580}, posted-at = {2008-12-11 01:46:45}, priority = {2}, title = {Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia.}, url = {http://dx.doi.org/10.1002/cncr.21776}, volume = {106}, year = {2006} }

TY - JOUR ID - citeulike:3772070 L3 - citeulike-article-id:3772070 N2 - BACKGROUND: Adult Burkitt-type lymphoma (BL) and acute lymphoblastic leukemia (B-ALL) are rare entities composing 1% to 5% of non-Hodgkin lymphomas NHL) or ALL. Prognosis of BL and B-ALL has been poor with conventional NHL or ALL regimens, but has improved with dose-intensive regimens. METHODS: To evaluate the addition of rituximab, a CD20 monoclonal antibody, to intensive chemotherapy in adults with BL or B-ALL, 31 patients with newly diagnosed BL or B-ALL received the hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) regimen with rituximab. Their median age was 46 years; 29% were 60 years or older. Rituximab 375 mg/m(2) was given on Days 1 and 11 of hyper-CVAD courses and on Days 1 and 8 of methotrexate and cytarabine courses. RESULTS: Complete remission (complete response [CR]) was achieved in 24 of 28 (86%) evaluable patients; 3 had a partial response, and 1 had resistant disease. There were no induction deaths. The 3-year overall survival (OS), event-free survival, and disease-free survival rates were 89%, 80%, and 88%, respectively. Nine elderly patients achieved CR with all of them in continuous CR (except 1 death in CR from infection), with a 3-year OS rate of 89%. Multivariate analysis of current and historical (those treated with hyper-CVAD alone) groups identified age and treatment with rituximab as favorable factors. CONCLUSIONS: The addition of rituximab to hyper-CVAD may improve outcome in adult BL or B-ALL, particularly in elderly patients. IS - 7 JF - Cancer SN - 0008-543X EP - 1580 TI - Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia. VL - 106 SP - 1569 KW - b-all KW - hypercvad AU - Thomas, DA AU - Faderl, S AU - O'Brien, S AU - Bueso-Ramos, C AU - Cortes, J AU - Garcia-Manero, G AU - Giles, FJ AU - Verstovsek, S AU - Wierda, WG AU - Pierce, SA AU - Shan, J AU - Brandt, M AU - Hagemeister, FB AU - Keating, MJ AU - Cabanillas, F AU - Kantarjian, H PY - 2006/04/01/ UR - http://dx.doi.org/10.1002/cncr.21776 ER -