Similar network activity from disparate circuit parameters Export

@article{PrinzBucherMarder2004SimilarActivityDisparateParameters, abstract = {It is often assumed that cellular and synaptic properties need to be regulated to specific values to allow a neuronal network to function properly. To determine how tightly neuronal properties and synaptic strengths need to be tuned to produce a given network output, we simulated more than 20 million versions of a three-cell model of the pyloric network of the crustacean stomatogastric ganglion using different combinations of synapse strengths and neuron properties. We found that virtually indistinguishable network activity can arise from widely disparate sets of underlying mechanisms, suggesting that there could be considerable animal-to-animal variability in many of the parameters that control network activity, and that many different combinations of synaptic strengths and intrinsic membrane properties can be consistent with appropriate network performance.}, author = {Prinz, Astrid A. and Bucher, Dirk and Marder, Eve}, citeulike-article-id = {229073}, citeulike-linkout-0 = {http://www.nature.com/neuro/journal/v7/n12/abs/nn1352.html}, comment = {important cautionary tale about taking between-subjects averages}, journal = {Nature Neuroscience}, keywords = {neuro}, month = {December}, number = {12}, pages = {1345--1352}, posted-at = {2005-06-16 05:55:18}, priority = {0}, title = {Similar network activity from disparate circuit parameters}, url = {http://www.nature.com/neuro/journal/v7/n12/abs/nn1352.html}, volume = {7}, year = {2004} }

TY - JOUR ID - PrinzBucherMarder2004SimilarActivityDisparateParameters L3 - citeulike-article-id:229073 N2 - It is often assumed that cellular and synaptic properties need to be regulated to specific values to allow a neuronal network to function properly. To determine how tightly neuronal properties and synaptic strengths need to be tuned to produce a given network output, we simulated more than 20 million versions of a three-cell model of the pyloric network of the crustacean stomatogastric ganglion using different combinations of synapse strengths and neuron properties. We found that virtually indistinguishable network activity can arise from widely disparate sets of underlying mechanisms, suggesting that there could be considerable animal-to-animal variability in many of the parameters that control network activity, and that many different combinations of synaptic strengths and intrinsic membrane properties can be consistent with appropriate network performance. IS - 12 JF - Nature Neuroscience EP - 1352 TI - Similar network activity from disparate circuit parameters VL - 7 SP - 1345 KW - neuro N1 - important cautionary tale about taking between-subjects averages AU - Prinz, Astrid AU - Bucher, Dirk AU - Marder, Eve PY - 2004/12// UR - http://www.nature.com/neuro/journal/v7/n12/abs/nn1352.html ER -