Prion proteins from susceptible and resistant sheep exhibit some distinct cell biological features. Export

@article{citeulike:3366431, abstract = {It is well established that natural polymorphisms in the coding sequence of the PrP protein can control the expression of prion disease. Studies with a cell model of sheep prion infection have shown that ovine PrP allele associated with resistance to sheep scrapie may confer resistance by impairing the multiplication of the infectious agent. To further explore the biochemical and cellular mechanisms underlying the genetic control of scrapie susceptibility, we established permissive cells expressing two different PrP variants. In this study, we show that PrP variants with opposite effects on prion multiplication exhibit distinct cell biological features. These findings indicate that cell biological properties of ovine PrP can vary with natural polymorphisms and raise the possibility that differential interactions of PrP variants with the cellular machinery may contribute to permissiveness or resistance to prion multiplication.}, author = {Sabuncu, E. and Paquet, S. and Chapuis, J. and Moudjou, M. and Lai, T. L. and Grassi, J. and Baron, U. and Laude, H. and Vilette, D.}, citeulike-article-id = {3366431}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbrc.2005.09.114}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16214113}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16214113}, day = {25}, doi = {10.1016/j.bbrc.2005.09.114}, issn = {0006-291X}, journal = {Biochemical and biophysical research communications}, keywords = {cellular\_model, prions}, month = {November}, number = {3}, pages = {791--798}, posted-at = {2008-10-02 14:46:46}, priority = {0}, title = {Prion proteins from susceptible and resistant sheep exhibit some distinct cell biological features.}, url = {http://dx.doi.org/10.1016/j.bbrc.2005.09.114}, volume = {337}, year = {2005} }

TY - JOUR ID - citeulike:3366431 L3 - citeulike-article-id:3366431 N2 - It is well established that natural polymorphisms in the coding sequence of the PrP protein can control the expression of prion disease. Studies with a cell model of sheep prion infection have shown that ovine PrP allele associated with resistance to sheep scrapie may confer resistance by impairing the multiplication of the infectious agent. To further explore the biochemical and cellular mechanisms underlying the genetic control of scrapie susceptibility, we established permissive cells expressing two different PrP variants. In this study, we show that PrP variants with opposite effects on prion multiplication exhibit distinct cell biological features. These findings indicate that cell biological properties of ovine PrP can vary with natural polymorphisms and raise the possibility that differential interactions of PrP variants with the cellular machinery may contribute to permissiveness or resistance to prion multiplication. IS - 3 JF - Biochemical and biophysical research communications SN - 0006-291X EP - 798 TI - Prion proteins from susceptible and resistant sheep exhibit some distinct cell biological features. VL - 337 SP - 791 KW - cellular_model KW - prions AU - Sabuncu, E AU - Paquet, S AU - Chapuis, J AU - Moudjou, M AU - Lai, TL AU - Grassi, J AU - Baron, U AU - Laude, H AU - Vilette, D PY - 2005/11/25/ UR - http://dx.doi.org/10.1016/j.bbrc.2005.09.114 ER -