Calcium Plus Vitamin D Supplementation and Mortality in Postmenopausal Women: The Women's Health Initiative Calcium-Vitamin D Randomized Controlled Trial Export

@article{citeulike:6086592, abstract = {BackgroundCalcium and vitamin D (CaD) supplementation trials including the Women's Health Initiative (WHI) trial of CaD have shown nonsignificant reductions in total mortality. This report examines intervention effects on total and cause-specific mortality by age and adherence. MethodsThe WHI CaD trial was a randomized, double-blind, placebo-controlled trial that enrolled 36,282 postmenopausal women aged 51-82 years from 40 U.S. clinical centers. Women were assigned to 1,000 mg of elemental calcium carbonate and 400 IU of vitamin D3 daily or placebo with average follow-up of 7.0 years. ResultsThe hazard ratio (HR) for total mortality was 0.91 (95\% confidence interval [CI], 0.83-1.01) with 744 deaths in women randomized to CaD versus 807 deaths in the placebo group. HRs were in the direction of reduced risk but nonsignificant for stroke and cancer mortality, but near unity for coronary heart disease and other causes of death. HRs for total mortality were 0.89 in the 29,942 women younger than 70 years (95\% CI, 0.79-1.01) and 0.95 in the 6,340 women aged 70 and older (95\% CI, 0.80-1.12; p value for age interaction = .10). No statistically significant interactions were observed for any baseline characteristics. Treatment effects did not vary significantly by season. ConclusionsIn the WHI CaD trial, supplementation did not have a statistically significant effect on mortality rates but the findings support the possibility that these supplements may reduce mortality rates in postmenopausal women. These data can neither support nor refute recommendations for higher dose vitamin D supplementation to reduce cancer or total mortality. 10.1093/gerona/glp006}, author = {LaCroix, Andrea Z. and Kotchen, Jane and Anderson, Garnet and Brzyski, Robert and Cauley, Jane A. and Cummings, Steven R. and Gass, Margery and Johnson, Karen C. and Ko, Marcia and Larson, Joseph and Manson, JoAnn E. and Stefanick, Marcia L. and Wactawski-Wende, Jean}, citeulike-article-id = {6086592}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/gerona/glp006}, citeulike-linkout-1 = {http://biomedgerontology.oxfordjournals.org/content/glp006v1/.abstract}, citeulike-linkout-2 = {http://biomedgerontology.oxfordjournals.org/content/glp006v1/.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19221190}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19221190}, day = {16}, doi = {10.1093/gerona/glp006}, journal = {J Gerontol A Biol Sci Med Sci}, keywords = {d, disease, heart, vitamin}, month = {February}, pages = {glp006+}, posted-at = {2009-11-08 20:13:19}, priority = {2}, title = {Calcium Plus Vitamin D Supplementation and Mortality in Postmenopausal Women: The Women's Health Initiative Calcium-Vitamin D Randomized Controlled Trial}, url = {http://dx.doi.org/10.1093/gerona/glp006}, year = {2009} }

TY - JOUR ID - citeulike:6086592 L3 - citeulike-article-id:6086592 N2 - BackgroundCalcium and vitamin D (CaD) supplementation trials including the Women's Health Initiative (WHI) trial of CaD have shown nonsignificant reductions in total mortality. This report examines intervention effects on total and cause-specific mortality by age and adherence. MethodsThe WHI CaD trial was a randomized, double-blind, placebo-controlled trial that enrolled 36,282 postmenopausal women aged 51-82 years from 40 U.S. clinical centers. Women were assigned to 1,000 mg of elemental calcium carbonate and 400 IU of vitamin D3 daily or placebo with average follow-up of 7.0 years. ResultsThe hazard ratio (HR) for total mortality was 0.91 (95% confidence interval [CI], 0.83-1.01) with 744 deaths in women randomized to CaD versus 807 deaths in the placebo group. HRs were in the direction of reduced risk but nonsignificant for stroke and cancer mortality, but near unity for coronary heart disease and other causes of death. HRs for total mortality were 0.89 in the 29,942 women younger than 70 years (95% CI, 0.79-1.01) and 0.95 in the 6,340 women aged 70 and older (95% CI, 0.80-1.12; p value for age interaction = .10). No statistically significant interactions were observed for any baseline characteristics. Treatment effects did not vary significantly by season. ConclusionsIn the WHI CaD trial, supplementation did not have a statistically significant effect on mortality rates but the findings support the possibility that these supplements may reduce mortality rates in postmenopausal women. These data can neither support nor refute recommendations for higher dose vitamin D supplementation to reduce cancer or total mortality. 10.1093/gerona/glp006 JF - J Gerontol A Biol Sci Med Sci TI - Calcium Plus Vitamin D Supplementation and Mortality in Postmenopausal Women: The Women's Health Initiative Calcium-Vitamin D Randomized Controlled Trial SP - glp006 KW - d KW - disease KW - heart KW - vitamin AU - LaCroix, Andrea AU - Kotchen, Jane AU - Anderson, Garnet AU - Brzyski, Robert AU - Cauley, Jane AU - Cummings, Steven AU - Gass, Margery AU - Johnson, Karen AU - Ko, Marcia AU - Larson, Joseph AU - Manson, JoAnn AU - Stefanick, Marcia AU - Wactawski-Wende, Jean PY - 2009/02/16/ UR - http://dx.doi.org/10.1093/gerona/glp006 ER -