Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs Export

@article{citeulike:3842970, abstract = {To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of \~{}10^6-10^9 decoy sites? Our analysis of 319 known TF binding motifs clearly demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations; eukaryotic TFs exhibit widespread nonfunctional binding and require clustering of sites in regulatory regions for specificity.}, archivePrefix = {arXiv}, author = {Mirny, Leonid A. and Wunderlich, Zeba}, citeulike-article-id = {3842970}, citeulike-linkout-0 = {http://arxiv.org/abs/0812.3910}, citeulike-linkout-1 = {http://arxiv.org/pdf/0812.3910}, day = {21}, eprint = {0812.3910}, keywords = {cis\_regulatory\_elements}, month = {Jan}, posted-at = {2009-09-16 14:27:59}, priority = {2}, title = {Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs}, url = {http://arxiv.org/abs/0812.3910}, year = {2009} }

TY - JOUR ID - citeulike:3842970 L3 - citeulike-article-id:3842970 N2 - To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6-10^9 decoy sites? Our analysis of 319 known TF binding motifs clearly demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations; eukaryotic TFs exhibit widespread nonfunctional binding and require clustering of sites in regulatory regions for specificity. TI - Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs KW - cis_regulatory_elements AU - Mirny, Leonid AU - Wunderlich, Zeba PY - 2009/Jan/21/ UR - http://arxiv.org/abs/0812.3910 ER -