Is Genetic Evolution Predictable? Export

@article{citeulike:4014590, abstract = {Ever since the integration of Mendelian genetics into evolutionary biology in the early 20th century, evolutionary geneticists have for the most part treated genes and mutations as generic entities. However, recent observations indicate that all genes are not equal in the eyes of evolution. Evolutionarily relevant mutations tend to accumulate in hotspot genes and at specific positions within genes. Genetic evolution is constrained by gene function, the structure of genetic networks, and population biology. The genetic basis of evolution may be predictable to some extent, and further understanding of this predictability requires incorporation of the specific functions and characteristics of genes into evolutionary theory. 10.1126/science.1158997}, author = {Stern, David L. and Orgogozo, Virginie}, citeulike-article-id = {4014590}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1158997}, citeulike-linkout-1 = {http://www.sciencemag.org/content/323/5915/746.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/323/5915/746.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/323/5915/746}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19197055}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19197055}, day = {6}, doi = {10.1126/science.1158997}, journal = {Science}, keywords = {cis\_regulatory\_variation, drosophila, natural\_selection, phenotypic\_evolution, review}, month = {February}, number = {5915}, pages = {746--751}, posted-at = {2009-10-27 04:55:04}, priority = {2}, title = {Is Genetic Evolution Predictable?}, url = {http://dx.doi.org/10.1126/science.1158997}, volume = {323}, year = {2009} }

TY - JOUR ID - citeulike:4014590 L3 - citeulike-article-id:4014590 N2 - Ever since the integration of Mendelian genetics into evolutionary biology in the early 20th century, evolutionary geneticists have for the most part treated genes and mutations as generic entities. However, recent observations indicate that all genes are not equal in the eyes of evolution. Evolutionarily relevant mutations tend to accumulate in hotspot genes and at specific positions within genes. Genetic evolution is constrained by gene function, the structure of genetic networks, and population biology. The genetic basis of evolution may be predictable to some extent, and further understanding of this predictability requires incorporation of the specific functions and characteristics of genes into evolutionary theory. 10.1126/science.1158997 IS - 5915 JF - Science EP - 751 TI - Is Genetic Evolution Predictable? VL - 323 SP - 746 KW - cis_regulatory_variation KW - drosophila KW - natural_selection KW - phenotypic_evolution KW - review AU - Stern, David AU - Orgogozo, Virginie PY - 2009/02/06/ UR - http://dx.doi.org/10.1126/science.1158997 ER -