Pervasive Natural Selection in the Drosophila Genome? Export

@article{citeulike:4751748, abstract = {<p>Over the past four decades, the predominant view of molecular evolution saw little connection between natural selection and genome evolution, assuming that the functionally constrained fraction of the genome is relatively small and that adaptation is sufficiently infrequent to play little role in shaping patterns of variation within and even between species. Recent evidence from <italic>Drosophila</italic>, reviewed here, suggests that this view may be invalid. Analyses of genetic variation within and between species reveal that much of the <italic>Drosophila</italic> genome is under purifying selection, and thus of functional importance, and that a large fraction of coding and noncoding differences between species are adaptive. The findings further indicate that, in <italic>Drosophila</italic>, adaptations may be both common and strong enough that the fate of neutral mutations depends on their chance linkage to adaptive mutations as much as on the vagaries of genetic drift. The emerging evidence has implications for a wide variety of fields, from conservation genetics to bioinformatics, and presents challenges to modelers and experimentalists alike.</p>}, author = {Sella, Guy and Petrov, Dmitri A. and Przeworski, Molly and Andolfatto, Peter}, citeulike-article-id = {4751748}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.1000495}, doi = {10.1371/journal.pgen.1000495}, issn = {1553-7404}, journal = {PLoS Genetics}, keywords = {adaptation, drosophila, natural\_selection, population\_genetics, review}, month = {June}, number = {6}, pages = {e1000495+}, posted-at = {2009-07-03 17:54:53}, priority = {2}, publisher = {Public Library of Science}, title = {Pervasive Natural Selection in the Drosophila Genome?}, url = {http://dx.doi.org/10.1371/journal.pgen.1000495}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:4751748 L3 - citeulike-article-id:4751748 N2 - <p>Over the past four decades, the predominant view of molecular evolution saw little connection between natural selection and genome evolution, assuming that the functionally constrained fraction of the genome is relatively small and that adaptation is sufficiently infrequent to play little role in shaping patterns of variation within and even between species. Recent evidence from <italic>Drosophila</italic>, reviewed here, suggests that this view may be invalid. Analyses of genetic variation within and between species reveal that much of the <italic>Drosophila</italic> genome is under purifying selection, and thus of functional importance, and that a large fraction of coding and noncoding differences between species are adaptive. The findings further indicate that, in <italic>Drosophila</italic>, adaptations may be both common and strong enough that the fate of neutral mutations depends on their chance linkage to adaptive mutations as much as on the vagaries of genetic drift. The emerging evidence has implications for a wide variety of fields, from conservation genetics to bioinformatics, and presents challenges to modelers and experimentalists alike.</p> IS - 6 JF - PLoS Genetics SN - 1553-7404 TI - Pervasive Natural Selection in the Drosophila Genome? PB - Public Library of Science VL - 5 SP - e1000495 KW - adaptation KW - drosophila KW - natural_selection KW - population_genetics KW - review AU - Sella, Guy AU - Petrov, Dmitri AU - Przeworski, Molly AU - Andolfatto, Peter PY - 2009/06/05/ UR - http://dx.doi.org/10.1371/journal.pgen.1000495 ER -