Spatial patterns of variation due to natural selection in humans Export

@article{citeulike:5971537, abstract = {Empowered by technology and sampling efforts designed to facilitate genome-wide association mapping, human geneticists are now studying the geography of genetic variation in unprecedented detail. With high genomic coverage and geographic resolution, these studies are identifying loci with spatial signatures of selection, such as extreme levels of differentiation and correlations with environmental variables. Collectively, patterns at these loci are beginning to provide new insights into the process of human adaptation. Here, we review the challenges of these studies and emerging results, including how human population structure has influenced the response to novel selective pressures.}, author = {Novembre, John and Di Rienzo, Anna}, citeulike-article-id = {5971537}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2632}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2632}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19823195}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19823195}, day = {13}, doi = {10.1038/nrg2632}, issn = {1471-0056}, journal = {Nat Rev Genet}, keywords = {human\_adaptation, natural\_selection, population\_genetics, spatial\_variation}, month = {October}, number = {11}, pages = {745--755}, posted-at = {2009-11-04 22:35:38}, priority = {2}, publisher = {Nature Publishing Group}, title = {Spatial patterns of variation due to natural selection in humans}, url = {http://dx.doi.org/10.1038/nrg2632}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5971537 L3 - citeulike-article-id:5971537 N2 - Empowered by technology and sampling efforts designed to facilitate genome-wide association mapping, human geneticists are now studying the geography of genetic variation in unprecedented detail. With high genomic coverage and geographic resolution, these studies are identifying loci with spatial signatures of selection, such as extreme levels of differentiation and correlations with environmental variables. Collectively, patterns at these loci are beginning to provide new insights into the process of human adaptation. Here, we review the challenges of these studies and emerging results, including how human population structure has influenced the response to novel selective pressures. IS - 11 JF - Nat Rev Genet SN - 1471-0056 EP - 755 TI - Spatial patterns of variation due to natural selection in humans PB - Nature Publishing Group VL - 10 SP - 745 KW - human_adaptation KW - natural_selection KW - population_genetics KW - spatial_variation AU - Novembre, John AU - Di Rienzo, Anna PY - 2009/10/13/ UR - http://dx.doi.org/10.1038/nrg2632 ER -