Network Evolution of Body Plans Export

@article{citeulike:3065816, abstract = {Segmentation in arthropod embryogenesis represents a well-known example of body plan diversity. Striped patterns of gene expression that lead to the future body segments appear simultaneously or sequentially in long and short germ-band development, respectively. Regulatory genes relevant for stripe formation are evolutionarily conserved among arthropods, therefore the differences in the observed traits are thought to have originated from how the genes are wired. To reveal the basic differences in the network structure, we have numerically evolved hundreds of gene regulatory networks that produce striped patterns of gene expression. By analyzing the topologies of the generated networks, we show that the characteristics of stripe formation in long and short germ-band development are determined by Feed-Forward Loops (FFLs) and negative Feed-Back Loops (FBLs) respectively. Network architectures, gene expression patterns and knockout responses exhibited by the artificially evolved networks agree with those reported in the fly Drosophila melanogaster and the beetle Tribolium castaneum. For other arthropod species, principal network architectures that remain largely unknown are predicted.}, archivePrefix = {arXiv}, author = {Fujimoto, Koichi and Ishihara, Shuji and Kaneko, Kunihiko}, citeulike-article-id = {3065816}, citeulike-linkout-0 = {http://arxiv.org/abs/0807.4784}, citeulike-linkout-1 = {http://arxiv.org/pdf/0807.4784}, day = {30}, eprint = {0807.4784}, keywords = {evolution, gene\_regulatory\_net, robustness}, month = {Jul}, posted-at = {2008-07-31 16:34:02}, priority = {3}, title = {Network Evolution of Body Plans}, url = {http://arxiv.org/abs/0807.4784}, year = {2008} }

TY - JOUR ID - citeulike:3065816 L3 - citeulike-article-id:3065816 N2 - Segmentation in arthropod embryogenesis represents a well-known example of body plan diversity. Striped patterns of gene expression that lead to the future body segments appear simultaneously or sequentially in long and short germ-band development, respectively. Regulatory genes relevant for stripe formation are evolutionarily conserved among arthropods, therefore the differences in the observed traits are thought to have originated from how the genes are wired. To reveal the basic differences in the network structure, we have numerically evolved hundreds of gene regulatory networks that produce striped patterns of gene expression. By analyzing the topologies of the generated networks, we show that the characteristics of stripe formation in long and short germ-band development are determined by Feed-Forward Loops (FFLs) and negative Feed-Back Loops (FBLs) respectively. Network architectures, gene expression patterns and knockout responses exhibited by the artificially evolved networks agree with those reported in the fly Drosophila melanogaster and the beetle Tribolium castaneum. For other arthropod species, principal network architectures that remain largely unknown are predicted. TI - Network Evolution of Body Plans KW - evolution KW - gene_regulatory_net KW - robustness AU - Fujimoto, Koichi AU - Ishihara, Shuji AU - Kaneko, Kunihiko PY - 2008/Jul/30/ UR - http://arxiv.org/abs/0807.4784 ER -